GEO DataSets

Analysis of kidneys from 30 day-old males representing SD, FHH, PCK, and FHH.Pkhd1 strains. The FHH.Pkhd1 strain carries the PCK Pkhd1 mutation but is resistant to the development of ARPKD. Results provide insight into the molecular mechanisms that modulate ARPKD disease progression and severity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 4 strain sets

Platform:

GPL1355

Series:

GSE33056

12 Samples

Download data: CEL

(Submitter supplied) To facilitate the search for genetic modifiers that modulate ARPKD disease progression and severity, we sought to generate a congenic rat model that carries the PCK Pkhd1 mutation but is resistant to the development of ARPKD. We transferred the Pkhd1 mutation from the PCK rat onto the genetic background of the FHH (Fawn-Hooded Hypertensive) rat. This newly developed strain, called FHH.Pkhd1, showed significant amelioration of renal disease, and delayed onset of biliary abnormalities. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS4492

Platform:

GPL1355

12 Samples

Download data: CEL

(Submitter supplied) Kidneys are enlarged by aberrant proliferation of tubule epithelial cells leading to the formation of numerous cysts, nephron loss, and interstitial fibrosis in polycystic kidney disease (PKD). Pioglitazone (PIO), a PPAR-γ agonist, decreased cell proliferation, interstitial fibrosis and inflammation, and ameliorated PKD progression in PCK rats. To examine the genetic mechanisms in this efficacy, we analyzed changes in global gene expression. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL4135

2 Samples

Download data: TXT

(Submitter supplied) Autosomal recessive polycystic kidney disease is a severe, monogenetically inherited kidney and liver disease and PCK rats carrying the orthologous mutant gene serve as a model of human disease. We combined selective MALDI imaging of sulfated kidney lipids and Fisher discriminant analysis of imaging data sets for identification of candidate lipid markers of progressive disease in PCK rats. Our study highlights strong increases in lower mass lipids as main classifiers of cystic disease. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL17378

12 Samples

Download data: CEL

(Submitter supplied) Microarray of kidney organoids derived from PKHD1 mutant human pluripotent stem cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13915

6 Samples

Download data: TXT

(Submitter supplied) Microarray was performed on kidneys in molsidomine-treated FHH rats in order to gain understanding why perinatal treatment with molsidomine in FHH was beneficial in FHH offspring (e.g. lower blood pressure and less renal damage)

Organism:

Rattus norvegicus

Type:

Genome variation profiling by SNP array

Platform:

GPL6101

62 Samples

Download data: TXT