GEO DataSets

Examination of kidney tissue from Sprague Dawley and Dahl salt sensitive (SS/Jr) rats fed 10 day diet of either 0.3% or 8.0% NaCl. Results provide insight into salt adaptation and pathogenesis of hypertension.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol, 2 strain sets

Platform:

GPL85

Series:

GSE599

11 Samples

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(Submitter supplied) Serum and glucocorticoid-induced kinase 1 (SGK1) activates the epithelial sodium channel (eNaC) in tubules. We examined renal SGK1 abundance in salt-adaptation and in salt-sensitive hypertension. Sprague-Dawley and Dahl salt-sensitive rats were placed on either 8% or 0.3% NaCl diets for 10 days. Plasma aldosterone levels were approximately 2.5-fold greater on 0.3% versus 8% NaCl diets in both rat strains. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS574

Platform:

GPL85

11 Samples

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(Submitter supplied) Serum and glucocorticoid-induced kinase 1 (SGK1) regulates blood pressure and has been implicated in inflammation and fibrosis. We have tested whether increased SGK1 activity potentiates mineralocorticoid/NaCl-induced hypertension and kidney injury. To that end we have used a transgenic mouse model with increased SGK1 activity (Tg.sgk1). This data set consists on transcriptomic analysis of kidney cortex samples to obtain differential gene expression due to excess SGK1 activity between wild type or Tg.sgk1 animals that were uninephrectomized and then treated with DOCA/NaCl

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

8 Samples

Download data: CEL

(Submitter supplied) Substitution of chromosome 13 from Brown Norway BN/SsNHsd/Mcw (BN/Mcw) rats into the Dahl salt-sensitive SS/JrHsd/Mcw (SS/Mcw) rats resulted in substantial reduction of blood pressure salt sensitivity in this consomic rat strain designated SSBN13. In the present study, we attempted to identify genes associated with salt-sensitive hypertension by utilizing a custom, known-gene cDNA microarray to compare the mRNA expression profiles in the renal medulla (a tissue playing a pivotal role in long-term blood pressure regulation) of SS/Mcw and SSBN13 rats on either low-salt (0.4% NaCl) or high-salt (4% NaCl, 2 wk) diets. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL3076

24 Samples

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