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Evi5 ecotropic viral integration site 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100360066, updated on 13-Apr-2024

Summary

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Official Symbol
Evi5provided by RGD
Official Full Name
ecotropic viral integration site 5provided by RGD
Primary source
RGD:2322879
See related
Ensembl:ENSRNOG00000002039 AllianceGenome:RGD:2322879
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and retrograde transport, endosome to Golgi. Predicted to be located in cytosol. Orthologous to human EVI5 (ecotropic viral integration site 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 358.4), Kidney (RPKM 235.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14p22
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (2020524..2166593)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (1875601..2021678)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (2892738..3038237)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene RuvB-like AAA ATPase 2, pseudogene 1 Neighboring gene small nucleolar RNA, C/D box 21 Neighboring gene 40S ribosomal protein S26-like Neighboring gene small ribosomal subunit protein eS26-like Neighboring gene ribosomal protein L5 Neighboring gene ubiquitin-conjugating enzyme E2D 2B Neighboring gene growth factor independent 1 transcriptional repressor Neighboring gene RNA polymerase II associated protein 2 Neighboring gene glomulin, FKBP associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. Fuchs E, et al. J Cell Biol, 2007 Jun 18. PMID 17562788, Free PMC Article
  2. Functional dissection of Rab GTPases involved in primary cilium formation. Yoshimura S, et al. J Cell Biol, 2007 Jul 30. PMID 17646400, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ecotropic viral integration site 5 protein homolog
Names
rCG57228-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271410.1 → NP_001258339.1  ecotropic viral integration site 5 protein homolog

    See identical proteins and their annotated locations for NP_001258339.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I6GMA4, A6KPH4, D3ZJN9
    Related
    ENSRNOP00000058347.4, ENSRNOT00000061630.5
    Conserved Domains (2) summary
    smart00164
    Location:160 → 368
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl11555
    Location:456 → 494
    DUF1129; Protein of unknown function (DUF1129)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    2020524..2166593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250525.5 → XP_006250587.1  ecotropic viral integration site 5 protein homolog isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZM01, A0A8I6GMA4
    Related
    ENSRNOP00000078953.1
    Conserved Domains (2) summary
    smart00164
    Location:160 → 368
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl11555
    Location:516 → 554
    DUF1129; Protein of unknown function (DUF1129)

  2. XM_006250523.4 → XP_006250585.3  ecotropic viral integration site 5 protein homolog isoform X1

  3. XM_006250526.4 → XP_006250588.3  ecotropic viral integration site 5 protein homolog isoform X4

  4. XM_039091539.2 → XP_038947467.2  ecotropic viral integration site 5 protein homolog isoform X2

  5. XM_006250527.4 → XP_006250589.3  ecotropic viral integration site 5 protein homolog isoform X5

  6. XM_006250528.4 → XP_006250590.3  ecotropic viral integration site 5 protein homolog isoform X6

  7. XM_063272787.1 → XP_063128857.1  ecotropic viral integration site 5 protein homolog isoform X10

  8. XM_063272786.1 → XP_063128856.1  ecotropic viral integration site 5 protein homolog isoform X9

  9. XM_063272785.1 → XP_063128855.1  ecotropic viral integration site 5 protein homolog isoform X7

  10. XM_039091540.2 → XP_038947468.1  ecotropic viral integration site 5 protein homolog isoform X7

    UniProtKB/TrEMBL
    A0A8I6ASB5
    Conserved Domains (2) summary
    smart00164
    Location:116 → 324
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:348 → 693
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  11. XM_006250533.5 → XP_006250595.1  ecotropic viral integration site 5 protein homolog isoform X8

    UniProtKB/TrEMBL
    A6KPH7
    Conserved Domains (2) summary
    smart00164
    Location:71 → 279
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl11555
    Location:427 → 465
    DUF1129; Protein of unknown function (DUF1129)

  12. XM_039091542.2 → XP_038947470.1  ecotropic viral integration site 5 protein homolog isoform X9

    UniProtKB/TrEMBL
    A0A8I6GMA4
    Conserved Domains (2) summary
    smart00164
    Location:2 → 187
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:211 → 556
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version

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