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ZNF891 zinc finger protein 891 [ Homo sapiens (human) ]

Gene ID: 101060200, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF891provided by HGNC
Official Full Name
zinc finger protein 891provided by HGNC
Primary source
HGNC:HGNC:38709
See related
Ensembl:ENSG00000214029 AllianceGenome:HGNC:38709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 1.3), thyroid (RPKM 0.9) and 24 other tissues See more
Orthologs
all
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Genomic context

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Location:
12q24.33
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (133104779..133130274, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (133162095..133187590, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133681365..133706860, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5134 Neighboring gene PTP4A1 pseudogene 2 Neighboring gene ZNF84 divergent transcript Neighboring gene zinc finger protein 84 Neighboring gene MPRA-validated peak2056 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7399 Neighboring gene zinc finger protein 140 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7400 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26228 Neighboring gene ribosomal protein L23a pseudogene 67 Neighboring gene zinc finger protein 10 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:133731795-133732994 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:133757799-133758323 Neighboring gene zinc finger protein 268

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The finished DNA sequence of human chromosome 12. Scherer SE, et al. Nature, 2006 Mar 16. PMID 16541075
  2. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
  3. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 891
Names
hCG1646157

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277291.2 → NP_001264220.1  zinc finger protein 891

    See identical proteins and their annotated locations for NP_001264220.1

    Status: VALIDATED

    Source sequence(s)
    AC026786, BC017932, DA004094, DB295002
    Consensus CDS
    CCDS59238.1
    UniProtKB/Swiss-Prot
    A8MT65
    Related
    ENSP00000437590.1, ENST00000537226.3
    Conserved Domains (6) summary
    smart00349
    Location:43 → 99
    KRAB; krueppel associated box
    COG5048
    Location:272 → 544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350 → 370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:348 → 370
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:43 → 82
    KRAB; KRAB box
    pfam13465
    Location:502 → 527
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    133104779..133130274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    133162095..133187590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MT65.2 GenPept UniProtKB/Swiss-Prot:A8MT65

Gene LinkOut

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