U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ptl-1 Microtubule-associated protein [ Caenorhabditis elegans ]

Gene ID: 175230, updated on 12-Jun-2024

Summary

Go to the top of the page Help
Gene symbol
ptl-1
Gene description
Microtubule-associated protein
Locus tag
CELE_F42G9.9
See related
AllianceGenome:WB:WBGene00004212
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables kinesin binding activity and microtubule binding activity. Involved in microtubule polymerization and positive regulation of nematode male tail tip morphogenesis. Located in axon. Is expressed in several structures, including intestine; nerve ring; neurons; pharynx; and vulval muscle. Used to study amyotrophic lateral sclerosis and tauopathy. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to several human genes including MAPT (microtubule associated protein tau). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ptl-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (765184..771391)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Mucin-5AC Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene Putative protein-tyrosine sulfotransferase Neighboring gene Peptidyl-prolyl cis-trans isomerase 6 Neighboring gene 4-trimethylaminobutyraldehyde dehydrogenase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Axon Injury-Induced Autophagy Activation Is Impaired in a C. elegans Model of Tauopathy. Ko SH, et al. Int J Mol Sci, 2020 Nov 13. PMID 33202845, Free PMC Article
  2. Caenorhabditis elegans models of tauopathy. Pir GJ, et al. FASEB J, 2017 Dec. PMID 29191965
  3. A nematode microtubule-associated protein, PTL-1, closely resembles its mammalian counterparts in overall molecular architecture. Hashi Y, et al. Biosci Biotechnol Biochem, 2016 Jun. PMID 26906882
  4. Regulation of age-related structural integrity in neurons by protein with tau-like repeats (PTL-1) is cell autonomous. Chew YL, et al. Sci Rep, 2014 Jun 5. PMID 24898126, Free PMC Article
  5. Aging in the nervous system of Caenorhabditis elegans. Chew YL, et al. Commun Integr Biol, 2013 Sep 1. PMID 24255742, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTL-1 functions via neurons to modulate SKN-1, clarifying the role of this protein in the stress response and longevity.
    Title: Neuronal protein with tau-like repeats (PTL-1) regulates intestinal SKN-1 nuclear accumulation in response to oxidative stress.
  2. The authors conclude that the spectrin and microtubule cytoskeletons work in combination to protect axons and dendrites from mechanical stress and propose that defects in beta-spectrin and tau may sensitize neurons to damage.
    Title: Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling.
  3. The molecular architecture of PTL-1 was proved to be analogous to its mammalian counterparts, MAP2, MAP4, and tau, strongly supporting their evolutionary relationships.
    Title: A nematode microtubule-associated protein, PTL-1, closely resembles its mammalian counterparts in overall molecular architecture.
  4. PTL-1 is important for the maintenance of neuronal health as animals age, as well as in the regulation of whole organism lifespan.
    Title: PTL-1 regulates neuronal integrity and lifespan in C. elegans.
  5. PTL-1 affects retrograde axonal transport of uncoordinated (UNC)-104 protein in Caenorhabditis elegans.
    Title: Tau/PTL-1 associates with kinesin-3 KIF1A/UNC-104 and affects the motor's motility characteristics in C. elegans neurons.
  6. PTL-1 is involved in mechanosensation as well as some aspect of embryogenesis.
    Title: The invertebrate microtubule-associated protein PTL-1 functions in mechanosensation and development in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables kinesin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Microtubule-associated protein
NP_001022576.1
  • Confirmed by transcript evidence
NP_001367353.1
  • Confirmed by transcript evidence
NP_001367354.1
  • Confirmed by transcript evidence
NP_001379577.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    765184..771391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381708.2 → NP_001367354.1  Microtubule-associated protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    P90973, Q17365
    Conserved Domains (2) summary
    pfam00418
    Location:367 → 396
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam03999
    Location:176 → 269
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  2. NM_001381707.2 → NP_001367353.1  Microtubule-associated protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17365, Q95QG4
    Conserved Domains (2) summary
    pfam00418
    Location:367 → 396
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam03999
    Location:176 → 269
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  3. NM_001027405.7 → NP_001022576.1  Microtubule-associated protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022576.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O02592, Q17364
    Conserved Domains (1) summary
    pfam00418
    Location:397 → 425
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  4. NM_001393262.1 → NP_001379577.1  Microtubule-associated protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KY94
    Conserved Domains (2) summary
    pfam00418
    Location:219 → 248
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam03999
    Location:28 → 121
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools