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glt-3 Putative sodium-dependent excitatory amino acid transporter glt-3 [ Caenorhabditis elegans ]

Gene ID: 177882, updated on 25-Apr-2024

Summary

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Gene symbol
glt-3
Gene description
Putative sodium-dependent excitatory amino acid transporter glt-3
Primary source
WormBase:WBGene00001621
Locus tag
CELE_K08F4.4
See related
AllianceGenome:WB:WBGene00001621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neutral amino acid transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in excretory cell and pharynx. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See glt-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (10130257..10133283)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Translocon-associated protein subunit beta Neighboring gene Uncharacterized protein Neighboring gene Ovule protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Guanosine Prevents against Glutamatergic Excitotoxicity in C. elegans. da Silveira TL, et al. Neuroscience, 2019 Aug 21. PMID 31306683
  2. The insulin/IGF signaling regulators cytohesin/GRP-1 and PIP5K/PPK-1 modulate susceptibility to excitotoxicity in C. elegans. Tehrani N, et al. PLoS One, 2014. PMID 25422944, Free PMC Article
  3. Caenorhabditis elegans glutamate transporter deletion induces AMPA-receptor/adenylyl cyclase 9-dependent excitotoxicity. Mano I, et al. J Neurochem, 2009 Mar. PMID 19054279
  4. Caenorhabditis elegans glutamate transporters influence synaptic function and behavior at sites distant from the synapse. Mano I, et al. J Biol Chem, 2007 Nov 23. PMID 17681948
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neutral amino acid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Putative sodium-dependent excitatory amino acid transporter glt-3
NP_501844.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10130257..10133283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069443.6 → NP_501844.1  Putative sodium-dependent excitatory amino acid transporter glt-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501844.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21353
    Conserved Domains (1) summary
    pfam00375
    Location:32 → 441
    SDF; Sodium:dicarboxylate symporter family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21353.1

Gene LinkOut

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