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Galk2 galactokinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296117, updated on 6-May-2024

Summary

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Official Symbol
Galk2provided by RGD
Official Full Name
galactokinase 2provided by RGD
Primary source
RGD:1308691
See related
Ensembl:ENSRNOG00000009289 AllianceGenome:RGD:1308691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable galactokinase activity. Predicted to be involved in galactose metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human GALK2 (galactokinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 207.2), Adrenal (RPKM 119.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q36
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (133563524..133696423)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (113110057..113243014)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (118137097..118268838)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene SECIS binding protein 2-like Neighboring gene TATA element modulatory factor 1, pseudogene 1 Neighboring gene COP9 signalosome subunit 2 Neighboring gene family with sequence similarity 227, member B Neighboring gene fibroblast growth factor 7 Neighboring gene DTW domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2. Ai Y, et al. Biochem Biophys Res Commun, 1995 Jul 17. PMID 7542884
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables N-acetylgalactosamine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables galactokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables galactokinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in galactose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galactose metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
N-acetylgalactosamine kinase
Names
galNAc kinase
NP_001013941.1
XP_006234968.1
XP_017447065.1
XP_038960484.1
XP_038960485.1
XP_038960486.1
XP_038960488.1
XP_038960489.1
XP_038960490.1
XP_063139392.1
XP_063139393.1
XP_063139394.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013919.2 → NP_001013941.1  N-acetylgalactosamine kinase isoform 1

    See identical proteins and their annotated locations for NP_001013941.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q5XIG6
    Related
    ENSRNOP00000012447.5, ENSRNOT00000012447.7
    Conserved Domains (3) summary
    PLN02521
    Location:18 → 455
    PLN02521; galactokinase
    pfam08544
    Location:350 → 430
    GHMP_kinases_C; GHMP kinases C terminal
    pfam10509
    Location:24 → 73
    GalKase_gal_bdg; Galactokinase galactose-binding signature

  2. NM_001430088.1 → NP_001417017.1  N-acetylgalactosamine kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NM_001430089.1 → NP_001417018.1  N-acetylgalactosamine kinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  4. NM_001430090.1 → NP_001417019.1  N-acetylgalactosamine kinase isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  5. NM_001430091.1 → NP_001417020.1  N-acetylgalactosamine kinase isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  6. NM_001430092.1 → NP_001417021.1  N-acetylgalactosamine kinase isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  7. NM_001430093.1 → NP_001417022.1  N-acetylgalactosamine kinase isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RNA

  1. NR_190852.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    133563524..133696423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104560.2 → XP_038960488.1  N-acetylgalactosamine kinase isoform X5

    UniProtKB/TrEMBL
    A6HPX9
    Conserved Domains (1) summary
    PLN02521
    Location:2 → 431
    PLN02521; galactokinase

  2. XM_063283324.1 → XP_063139394.1  N-acetylgalactosamine kinase isoform X6

  3. XM_063283323.1 → XP_063139393.1  N-acetylgalactosamine kinase isoform X4

  4. XM_039104557.2 → XP_038960485.1  N-acetylgalactosamine kinase isoform X3

    UniProtKB/TrEMBL
    A0A0G2JTQ5
    Related
    ENSRNOP00000068802.1
    Conserved Domains (1) summary
    PLN02521
    Location:7 → 444
    PLN02521; galactokinase

  5. XM_017591576.3 → XP_017447065.1  N-acetylgalactosamine kinase isoform X7

    UniProtKB/TrEMBL
    A0A8L2UPK8
    Related
    ENSRNOP00000069500.2

  6. XM_039104558.2 → XP_038960486.1  N-acetylgalactosamine kinase isoform X9

    Conserved Domains (1) summary
    PLN02521
    Location:29 → 384
    PLN02521; galactokinase

  7. XM_039104556.2 → XP_038960484.1  N-acetylgalactosamine kinase isoform X2

    Conserved Domains (1) summary
    PLN02521
    Location:18 → 394
    PLN02521; galactokinase

  8. XM_006234906.5 → XP_006234968.1  N-acetylgalactosamine kinase isoform X8

    Conserved Domains (2) summary
    PLN02521
    Location:1 → 395
    PLN02521; galactokinase
    pfam08544
    Location:290 → 370
    GHMP_kinases_C; GHMP kinases C terminal

  9. XM_063283322.1 → XP_063139392.1  N-acetylgalactosamine kinase isoform X1

  10. XM_039104562.2 → XP_038960490.1  N-acetylgalactosamine kinase isoform X10

    Conserved Domains (1) summary
    PLN02521
    Location:1 → 267
    PLN02521; galactokinase

  11. XM_039104561.2 → XP_038960489.1  N-acetylgalactosamine kinase isoform X10

    Conserved Domains (1) summary
    PLN02521
    Location:1 → 267
    PLN02521; galactokinase

RNA

  1. XR_005501815.2 RNA Sequence

  2. XR_005501816.2 RNA Sequence

  3. XR_005501813.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIG6.1 GenPept UniProtKB/Swiss-Prot:Q5XIG6

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