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atp1b3a ATPase Na+/K+ transporting subunit beta 3a [ Danio rerio (zebrafish) ]

Gene ID: 30468, updated on 27-Mar-2024

Summary

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Official Symbol
atp1b3aprovided by ZNC
Official Full Name
ATPase Na+/K+ transporting subunit beta 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-167
See related
Ensembl:ENSDARG00000015790 AllianceGenome:ZFIN:ZDB-GENE-990415-167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb713; atp1b3; nakatpb; wu:fa14a07
Summary
Predicted to enable ATPase activator activity. Predicted to be involved in cellular monovalent inorganic cation homeostasis and inorganic cation transmembrane transport. Predicted to act upstream of or within potassium ion transport and sodium ion transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of sodium:potassium-exchanging ATPase complex. Is expressed in several structures, including anterior axial hypoblast; immature eye; mesoderm; nervous system; and neural tube. Orthologous to human ATP1B3 (ATPase Na+/K+ transporting subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See atp1b3a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (16547706..16565691, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (16879116..16897098, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100002071 Neighboring gene uncharacterized LOC108179626 Neighboring gene G protein-coupled receptor kinase 7a Neighboring gene major histocompatibility complex class I HAA Neighboring gene 5'-3' exoribonuclease 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Differential expression of Na,K-ATPase alpha and beta subunit genes in the developing zebrafish inner ear. Blasiole B, et al. Dev Dyn, 2003 Nov. PMID 14579377
  2. Cellular and molecular bases of axonal pathfinding during embryogenesis of the fish central nervous system. Bernhardt RR. J Neurobiol, 1999 Jan. PMID 10027569
  3. Na(+) K(+) ATPase isoform switching in zebrafish during transition to dilute freshwater habitats. Esbaugh AJ, et al. Proc Biol Sci, 2019 May 29. PMID 31113326, Free PMC Article
  4. Depletion of Tissue-Specific Ion Transporters Causes Differential Expression of PRL Targets in Response to Increased Levels of Endogenous PRL. Shu T, et al. Front Endocrinol (Lausanne), 2018. PMID 30515132, Free PMC Article
  5. Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history. Castro LF, et al. Proc Biol Sci, 2014 Jan 22. PMID 24307675, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. There are different functional roles for individual Na,K-ATPase genes in zebrafish ear development
    Title: Differential expression of Na,K-ATPase alpha and beta subunit genes in the developing zebrafish inner ear.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of sodium:potassium-exchanging ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of sodium:potassium-exchanging ATPase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sodium/potassium-transporting ATPase subunit beta-3; sodium/potassium-transporting ATPase subunit beta-3a
Names
ATPase, Na+/K+ beta 3 polypeptide
ATPase, Na+/K+ beta 3a polypeptide
ATPase, Na+/K+ transporting, beta 3a polypeptide
NA,K-ATPase B subunit
etID309715.2
NP_571296.2
XP_021334400.1
XP_021334407.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131221.2 → NP_571296.2  sodium/potassium-transporting ATPase subunit beta-3a

    See identical proteins and their annotated locations for NP_571296.2

    Status: VALIDATED

    Source sequence(s)
    CR377211, EB862992, EH580086
    UniProtKB/TrEMBL
    Q6NZW6, Q8QHI1
    Related
    ENSDARP00000013993.7, ENSDART00000022549.10
    Conserved Domains (1) summary
    pfam00287
    Location:13 → 271
    Na_K-ATPase; Sodium / potassium ATPase beta chain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    16547706..16565691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478725.1 → XP_021334400.1  sodium/potassium-transporting ATPase subunit beta-3 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QJR8
    Conserved Domains (1) summary
    pfam00287
    Location:12 → 224
    Na_K-ATPase; Sodium / potassium ATPase beta chain

  2. XM_021478732.1 → XP_021334407.1  sodium/potassium-transporting ATPase subunit beta-3 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PS98
    Conserved Domains (1) summary
    pfam00287
    Location:12 → 194
    Na_K-ATPase; Sodium / potassium ATPase beta chain
Nucleotide Protein Strain
Heading Accession and Version

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