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c3a.2 complement C3a, tandem duplicate 2 [ Danio rerio (zebrafish) ]

Gene ID: 30491, updated on 8-Jun-2024

Summary

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Official Symbol
c3a.2provided by ZNC
Official Full Name
complement C3a, tandem duplicate 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-36
See related
Ensembl:ENSDARG00000087359 AllianceGenome:ZFIN:ZDB-GENE-990415-36
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
c3b; C3-1; C3-2
Summary
Predicted to enable endopeptidase inhibitor activity. Acts upstream of or within cellular response to estrogen stimulus. Predicted to be located in extracellular space. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and post-vent region. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See c3a.2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
41
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (56229657..56266728)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (55560378..55597432)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 1C Neighboring gene zgc:65894 Neighboring gene complement C3a, tandem duplicate 3 Neighboring gene glucagon receptor b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Heat-inactivated Mycobacterium bovis protects zebrafish against mycobacteriosis. López V, et al. J Fish Dis, 2018 Oct. PMID 29956837
  2. Control of mycobacteriosis in zebrafish (Danio rerio) mucosally vaccinated with heat-inactivated Mycobacterium bovis. Risalde MA, et al. Vaccine, 2018 Jul 16. PMID 29935860
  3. Identification and innate immunity mechanism of protective immunogens from extracellular proteins of Edwardsiella tarda. Li L, et al. Fish Shellfish Immunol, 2020 Feb. PMID 31830569
  4. Dualistic immunomodulation of sub-chronic microcystin-LR exposure on the innate-immune defense system in male zebrafish. Lin W, et al. Chemosphere, 2017 Sep. PMID 28551208
  5. Dietary β-glucan enhances the contents of complement component 3 and factor B in eggs of zebrafish. Jiang C, et al. Dev Comp Immunol, 2016 Dec. PMID 27375187

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to estrogen stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
complement C3a.2; complement component c3a, duplicate 2
Names
c3.2
complement component C3-1
complement component c3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131243.1 → NP_571318.1  complement C3a.2 precursor

    See identical proteins and their annotated locations for NP_571318.1

    Status: PROVISIONAL

    Source sequence(s)
    AB235997
    UniProtKB/TrEMBL
    Q3MU74
    Related
    ENSDARP00000108724.3, ENSDART00000127714.5
    Conserved Domains (9) summary
    cd00017
    Location:674 → 729
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:987 → 1272
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    cd03583
    Location:1502 → 1649
    NTR_complement_C3; NTR/C345C domain, complement C3 subfamily; The NTR domain found in complement C3 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C3 plays a pivotal role in the activation of the complement ...
    pfam00207
    Location:768 → 861
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:128 → 222
    A2M_N; MG2 domain
    pfam02488
    Location:388 → 469
    EMA; Merozoite Antigen
    pfam07677
    Location:1387 → 1482
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:1042 → 1272
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:463 → 599
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    56229657..56266728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478306.1 → XP_021333981.1  complement component c3a, duplicate 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QDV0
    Conserved Domains (5) summary
    cd00017
    Location:674 → 729
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    pfam02488
    Location:388 → 469
    EMA; Merozoite Antigen
    pfam00207
    Location:768 → 861
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:128 → 222
    A2M_N; MG2 domain
    pfam07703
    Location:461 → 602
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
Nucleotide Protein Strain
Heading Accession and Version

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