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mhc1uba major histocompatibility complex class I UBA [ Danio rerio (zebrafish) ]

Gene ID: 30757, updated on 27-Mar-2024

Summary

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Official Symbol
mhc1ubaprovided by ZNC
Official Full Name
major histocompatibility complex class I UBAprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-145
See related
Ensembl:ENSDARG00000075963 AllianceGenome:ZFIN:ZDB-GENE-990415-145
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:91955
Summary
Predicted to be involved in immune response. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in liver and biliary system and pancreatic system. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); eye disease (multiple); human immunodeficiency virus infectious disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including MR1 (major histocompatibility complex, class I-related). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See mhc1uba in Genome Data Viewer
Location:
chromosome: 19
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (7072854..7101100)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (7153929..7182175)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex class I UKA Neighboring gene TAP binding protein (tapasin), tandem duplicate 2 Neighboring gene proteasome 20S subunit beta 8A Neighboring gene proteasome 20S subunit beta 13a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Conservation of an alpha 2 domain within the teleostean world, MHC class I from the rainbow trout Oncorhynchus mykiss. Hansen JD, et al. Dev Comp Immunol, 1996 Nov-Dec. PMID 9040984
  2. Ancestral TCDD Exposure Induces Multigenerational Histologic and Transcriptomic Alterations in Gonads of Male Zebrafish. Meyer DN, et al. Toxicol Sci, 2018 Aug 1. PMID 29788325, Free PMC Article
  3. Therapeutic Silencing of Centromere Protein X Ameliorates Hyperglycemia in Zebrafish and Mouse Models of Type 2 Diabetes Mellitus. Zang L, et al. Front Genet, 2019. PMID 31417608, Free PMC Article
  4. Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis. Moreno Traspas R, et al. Nat Genet, 2022 Aug. PMID 35864190, Free PMC Article
  5. Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes. Wu XM, et al. Dev Comp Immunol, 2017 Mar. PMID 27876605

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
major histocompatibility complex class I UBA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131471.1 → NP_571546.1  major histocompatibility complex class I UBA precursor

    See identical proteins and their annotated locations for NP_571546.1

    Status: PROVISIONAL

    Source sequence(s)
    Z46777
    UniProtKB/TrEMBL
    Q31365
    Related
    ENSDARP00000020667.7, ENSDART00000009689.8
    Conserved Domains (2) summary
    cd07698
    Location:198 → 294
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:21 → 194
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    7072854..7101100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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