U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Shroom2 shroom family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 317435, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Shroom2provided by RGD
Official Full Name
shroom family member 2provided by RGD
Primary source
RGD:1565163
See related
Ensembl:ENSRNOG00000024322 AllianceGenome:RGD:1565163
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Apxl; Ab2-404
Summary
Predicted to enable actin filament binding activity; beta-catenin binding activity; and protein domain specific binding activity. Predicted to be involved in actin filament organization; cell migration; and melanosome organization. Predicted to act upstream of or within cell-cell junction maintenance and negative regulation of actin filament depolymerization. Predicted to be located in several cellular components, including bicellular tight junction; cell cortex; and neuronal cell body. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Orthologous to human SHROOM2 (shroom family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 89.7), Brain (RPKM 76.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
Xq13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (25308163..25480194, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (21812469..21983724, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (23478869..23649424, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene RAB7A, member RAS oncogene family, pseudogene 1 Neighboring gene spermatogenesis associated multipass transmembrane protein 2 like 3 Neighboring gene G protein-coupled receptor 143 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization and functional analysis of the mouse Shroom2 ortholog.
    Title: Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
NOT involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell-cell junction maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in melanosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in melanosome organization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in apical junction complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical junction complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein Shroom2
Names
apical protein-like
liver regeneration-related protein LRRG167
protein Apxl

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001047893.3 → NP_001041358.2  protein Shroom2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I6A0R5, D4A053
    Related
    ENSRNOP00000056187.4, ENSRNOT00000059431.5
    Conserved Domains (3) summary
    cd00992
    Location:24 → 105
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08687
    Location:1196 → 1484
    ASD2; Apx/Shroom domain ASD2
    pfam08688
    Location:665 → 839
    ASD1; Apx/Shroom domain ASD1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    25308163..25480194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256817.4 → XP_006256879.1  protein Shroom2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A0R5
    Conserved Domains (3) summary
    cd00992
    Location:24 → 105
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08687
    Location:1190 → 1478
    ASD2; Apx/Shroom domain ASD2
    pfam08688
    Location:665 → 839
    ASD1; Apx/Shroom domain ASD1

  2. XM_006256816.5 → XP_006256878.1  protein Shroom2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A0R5
    Conserved Domains (3) summary
    cd00992
    Location:24 → 105
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08687
    Location:1191 → 1479
    ASD2; Apx/Shroom domain ASD2
    pfam08688
    Location:665 → 839
    ASD1; Apx/Shroom domain ASD1

  3. XM_008773126.4 → XP_008771348.1  protein Shroom2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A0R5
    Related
    ENSRNOP00000092823.1
    Conserved Domains (3) summary
    cd00992
    Location:24 → 105
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08687
    Location:1152 → 1440
    ASD2; Apx/Shroom domain ASD2
    pfam08688
    Location:621 → 795
    ASD1; Apx/Shroom domain ASD1

  4. XM_008773129.4 → XP_008771351.1  protein Shroom2 isoform X4

    See identical proteins and their annotated locations for XP_008771351.1

    Conserved Domains (1) summary
    pfam08687
    Location:151 → 439
    ASD2; Apx/Shroom domain ASD2

  5. XM_008773130.4 → XP_008771352.1  protein Shroom2 isoform X4

    See identical proteins and their annotated locations for XP_008771352.1

    Conserved Domains (1) summary
    pfam08687
    Location:151 → 439
    ASD2; Apx/Shroom domain ASD2

  6. XM_008773128.4 → XP_008771350.1  protein Shroom2 isoform X4

    See identical proteins and their annotated locations for XP_008771350.1

    Conserved Domains (1) summary
    pfam08687
    Location:151 → 439
    ASD2; Apx/Shroom domain ASD2

  7. XM_008773131.3 → XP_008771353.1  protein Shroom2 isoform X4

    See identical proteins and their annotated locations for XP_008771353.1

    Conserved Domains (1) summary
    pfam08687
    Location:151 → 439
    ASD2; Apx/Shroom domain ASD2

  8. XM_008773127.4 → XP_008771349.1  protein Shroom2 isoform X4

    See identical proteins and their annotated locations for XP_008771349.1

    Conserved Domains (1) summary
    pfam08687
    Location:151 → 439
    ASD2; Apx/Shroom domain ASD2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138859.1: Suppressed sequence

    Description
    NM_138859.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TP36.1 GenPept UniProtKB/Swiss-Prot:Q7TP36

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous