U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dna2 DNA replication helicase/nuclease 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31934, updated on 26-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Dna2provided by FlyBase
Official Full Name
DNA replication helicase/nuclease 2provided by FlyBase
Primary source
FLYBASE:FBgn0288690
Locus tag
Dmel_CG2990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2990; DmDNA2; Dmel\CG2990; DNA2; l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107; mus109
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9A4-9A4; 1-30 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10010481..10014279)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9904514..9908312)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chitinase 6 Neighboring gene antisense RNA:CR45185 Neighboring gene Yolk protein 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Drosophila Mutagen-Sensitivity Gene mus109 Encodes DmDNA2. Mitchell C, et al. Genes (Basel), 2022 Feb 7. PMID 35205357, Free PMC Article
  2. Isolation of two X-linked mutants in Drosophila melanogaster which are sensitive to gamma-rays. Nguyen TD, et al. Mutat Res, 1978 Jan. PMID 414131
  3. The maxillary palp of Drosophila: ultrastructure and physiology depends on the lozenge gene. Riesgo-Escovar JR, et al. J Comp Physiol A, 1997 Feb. PMID 9011067
  4. Mutagen sensitivity of Drosophila melanogaster. III. X-linked loci governing sensitivity to methyl methanesulfonate. Smith PD. Mol Gen Genet, 1976 Nov 24. PMID 189178
  5. Identification of a new locus, mus115, in Drosophila melanogaster. Leonhardt EA, et al. Mutat Res, 1993 Feb. PMID 7678169

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5'-3' DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 5'-flap endonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DNA replication helicase/nuclease 2
Names
CG2990-PB
CG2990-PC
DNA helicase
Dna2-PB
Dna2-PC
mutagen-sensitive 109
NP_001096933.1
NP_727386.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    10010481..10014279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167214.2 → NP_727386.1  DNA replication helicase/nuclease 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727386.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH96, Q8IRL9
    Related
    FBpp0071350
    Conserved Domains (5) summary
    TIGR00376
    Location:480 → 1069
    TIGR00376; DNA helicase, putative
    pfam08696
    Location:99 → 297
    Dna2; DNA replication factor Dna2
    pfam13087
    Location:815 → 1055
    AAA_12; AAA domain
    cl00641
    Location:283 → 415
    Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4
    cl21455
    Location:636 → 859
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001103463.2 → NP_001096933.1  DNA replication helicase/nuclease 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096933.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH96, Q9W2Z4
    Conserved Domains (5) summary
    TIGR00376
    Location:479 → 1068
    TIGR00376; DNA helicase, putative
    pfam08696
    Location:99 → 296
    Dna2; DNA replication factor Dna2
    pfam13087
    Location:814 → 1054
    AAA_12; AAA domain
    cl00641
    Location:282 → 414
    Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4
    cl21455
    Location:635 → 858
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86D36 Q86D36
Q8IRL9 Q8IRL9
Q9W2Z4 Q9W2Z4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous