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ap1g1 adaptor related protein complex 1 subunit gamma 1 [ Danio rerio (zebrafish) ]

Gene ID: 324466, updated on 27-Mar-2024

Summary

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Official Symbol
ap1g1provided by ZNC
Official Full Name
adaptor related protein complex 1 subunit gamma 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3187
See related
Ensembl:ENSDARG00000102394 AllianceGenome:ZFIN:ZDB-GENE-030131-3187
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
adtg; zgc:56079; wu:fc30a11
Summary
Predicted to enable clathrin adaptor activity. Acts upstream of or within several processes, including axis elongation; pectoral fin development; and vasculature development. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and membrane. Predicted to be part of AP-1 adaptor complex. Is expressed in liver and midbrain hindbrain boundary. Orthologous to human AP1G1 (adaptor related protein complex 1 subunit gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See ap1g1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (69304486..69352497, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (68999085..69115145, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene MARVEL domain containing 3 Neighboring gene PH domain and leucine rich repeat protein phosphatase 2 Neighboring gene uncharacterized LOC110439960 Neighboring gene zinc finger protein 821 Neighboring gene ataxin 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Deficiency of AP1 Complex Ap1g1 in Zebrafish Model Led to Perturbation of Neurodevelopment, Female and Male Fertility; New Insight to Understand Adaptinopathies. Mignani L, et al. Int J Mol Sci, 2023 Apr 12. PMID 37108275, Free PMC Article
  2. γ2 and γ1AP-1 complexes: Different essential functions and regulatory mechanisms in clathrin-dependent protein sorting. Zizioli D, et al. Eur J Cell Biol, 2017 Jun. PMID 28372831
  3. PI4K2β/AP-1-based TGN-endosomal sorting regulates Wnt signaling. Wieffer M, et al. Curr Biol, 2013 Nov 4. PMID 24206846
  4. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency of AP1 Complex Ap1g1 in Zebrafish Model Led to Perturbation of Neurodevelopment, Female and Male Fertility; New Insight to Understand Adaptinopathies.
    Title: Deficiency of AP1 Complex Ap1g1 in Zebrafish Model Led to Perturbation of Neurodevelopment, Female and Male Fertility; New Insight to Understand Adaptinopathies.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axis elongation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within axis elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within central nervous system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pectoral fin development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vasculature development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-1 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-1 adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AP-1 complex subunit gamma-1
Names
adaptor protein complex AP-1, gamma 1 subunit
adaptor-related protein complex 1, gamma 1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199682.1 → NP_955976.1  AP-1 complex subunit gamma-1

    See identical proteins and their annotated locations for NP_955976.1

    Status: PROVISIONAL

    Source sequence(s)
    BC047823
    UniProtKB/TrEMBL
    Q7ZUU8
    Related
    ENSDARP00000139530.1, ENSDART00000170714.3
    Conserved Domains (3) summary
    smart00809
    Location:706 → 814
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:23 → 573
    Adaptin_N; Adaptin N terminal region
    sd00044
    Location:142 → 163
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    69304486..69352497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017356817.2 → XP_017212306.1  AP-1 complex subunit gamma-1 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z1G8

  2. XM_017356815.2 → XP_017212304.1  AP-1 complex subunit gamma-1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YZX7

  3. XM_017356816.2 → XP_017212305.1  AP-1 complex subunit gamma-1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YZX7
Nucleotide Protein Strain
Heading Accession and Version

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