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dnajb1b DnaJ heat shock protein family (Hsp40) member B1b [ Danio rerio (zebrafish) ]

Gene ID: 327244, updated on 27-Mar-2024

Summary

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Official Symbol
dnajb1bprovided by ZNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member B1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5455
See related
Ensembl:ENSDARG00000041394 AllianceGenome:ZFIN:ZDB-GENE-030131-5455
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dnj-13C; fd19c10; zgc:55492; wu:fd19c10; CH73-341P18.4
Summary
Predicted to enable several functions, including Hsp70 protein binding activity; chaperone binding activity; and unfolded protein binding activity. Acts upstream of or within lens development in camera-type eye. Predicted to be active in cytosol. Is expressed in lens; neural plate; optic tectum; and solid lens vesicle. Orthologous to human DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (55745878..55749997, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (55068227..55072346, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909388 Neighboring gene putative adhesion G protein-coupled receptor E4P Neighboring gene adhesion G protein-coupled receptor E10 Neighboring gene trans-2,3-enoyl-CoA reductase b Neighboring gene uncharacterized LOC101884156 Neighboring gene NADH:ubiquinone oxidoreductase subunit B7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma. de Oliveira S, et al. Dis Model Mech, 2020 Apr 30. PMID 32102783, Free PMC Article
  2. Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate. Taler K, et al. Dev Biol, 2020 Feb 15. PMID 31669351
  3. FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1. Khan SY, et al. Nat Commun, 2016 Apr 6. PMID 27218149, Free PMC Article
  4. Transcriptomic profile of early zebrafish PGCs by single cell sequencing. Zhang X, et al. PLoS One, 2019. PMID 31412047, Free PMC Article
  5. The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Hawkins TA, et al. Development, 2008 Mar. PMID 18256191, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lens development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily B member 1b
Names
DnaJ (Hsp40) homolog, subfamily B, member 1
DnaJ (Hsp40) homolog, subfamily B, member 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199773.1 → NP_956067.1  dnaJ homolog subfamily B member 1b

    See identical proteins and their annotated locations for NP_956067.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045359
    UniProtKB/TrEMBL
    Q7ZVY8
    Related
    ENSDARP00000121420.2, ENSDART00000142244.3
    Conserved Domains (3) summary
    cd10747
    Location:160 → 322
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:1 → 328
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:4 → 65
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    55745878..55749997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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