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Nle Notchless [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33234, updated on 10-May-2024

Summary

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Official Symbol
Nleprovided by FlyBase
Official Full Name
Notchlessprovided by FlyBase
Primary source
FLYBASE:FBgn0021874
Locus tag
Dmel_CG2863
See related
AllianceGenome:FB:FBgn0021874
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0026364; CG2863; Dmel\CG2863; l(2)k13714; nle
Summary
Enables Notch binding activity. Involved in negative regulation of Notch signaling pathway and positive regulation of Notch signaling pathway. Predicted to be active in nucleolus. Is expressed in several structures, including embryonic/larval lymph gland; embryonic/larval muscle system; extended germ band embryo; gut section; and proventriculus primordium. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Nle in Genome Data Viewer
Location:
21E2-21E2; 2-1.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (566366..568121, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (566366..568121, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene reduced mechanoreceptor potential A Neighboring gene uncharacterized nascent polypeptide-associated complex beta subunit Neighboring gene Translocator protein Neighboring gene uncharacterized protein Neighboring gene Splicing factor 3b subunit 1 Neighboring gene Inositol phosphate kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation. Rørth P, et al. Mol Cell, 2000 Jul. PMID 10949024
  2. Relating past and present diet to phenotypic and transcriptomic variation in the fruit fly. May CM, et al. BMC Genomics, 2017 Aug 22. PMID 28830340, Free PMC Article
  3. Notch signaling: a dance of proteins changing partners. Kadesch T. Exp Cell Res, 2000 Oct 10. PMID 11010805
  4. Notchless encodes a novel WD40-repeat-containing protein that modulates Notch signaling activity. Royet J, et al. EMBO J, 1998 Dec 15. PMID 9857191, Free PMC Article
  5. Notch signaling in the nervous system. Pieces still missing from the puzzle. Baker NE. Bioessays, 2000 Mar. PMID 10684586

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Notch binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
notchless
Names
CG2863-PA
Nle-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    566366..568121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057946.4 → NP_477294.2  notchless [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477294.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96995, Q8T4A2, Q9VPR4
    Related
    FBpp0077735
    Conserved Domains (5) summary
    COG2319
    Location:112 → 486
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:153 → 487
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam00400
    Location:110 → 147
    WD40; WD domain, G-beta repeat
    pfam08154
    Location:22 → 82
    NLE; NLE (NUC135) domain
    sd00039
    Location:164 → 202
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPR4.2 Q9VPR4

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