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hsd11b2 hydroxysteroid (11-beta) dehydrogenase 2 [ Danio rerio (zebrafish) ]

Gene ID: 334098, updated on 1-Jun-2024

Summary

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Official Symbol
hsd11b2provided by ZNC
Official Full Name
hydroxysteroid (11-beta) dehydrogenase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6030
See related
Ensembl:ENSDARG00000001975 AllianceGenome:ZFIN:ZDB-GENE-030131-6030
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
11-DH2; wu:fi31d01
Summary
Predicted to enable oxidoreductase activity. Acts upstream of or within cortisol metabolic process and multicellular organismal response to stress. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; cardiovascular system; digestive system; endocrine system; and eye. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See hsd11b2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (35112052..35126343, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (34840575..34854866, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V0 subunit d1 Neighboring gene agouti related neuropeptide Neighboring gene zinc finger DHHC-type containing 1 Neighboring gene tubulin polymerization-promoting protein family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Knockout of the hsd11b2 Gene Extends the Cortisol Stress Response in Both Zebrafish Larvae and Adults. Theodoridi A, et al. Int J Mol Sci, 2021 Nov 20. PMID 34830405, Free PMC Article
  2. Species-specific differences in the inhibition of 11β-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole. Inderbinen SG, et al. Toxicol Appl Pharmacol, 2021 Feb 1. PMID 33387577
  3. Maternal stress-associated cortisol stimulation may protect embryos from cortisol excess in zebrafish. Faught E, et al. R Soc Open Sci, 2016 Feb. PMID 26998341, Free PMC Article
  4. Species-specific differences in the inhibition of human and zebrafish 11β-hydroxysteroid dehydrogenase 2 by thiram and organotins. Meyer A, et al. Toxicology, 2012 Nov 15. PMID 22796344
  5. Cloning, expression and enzyme activity analysis of testicular 11beta-hydroxysteroid dehydrogenase during seasonal cycle and after hCG induction in air-breathing catfish Clarias gariepinus. Rasheeda MK, et al. J Steroid Biochem Mol Biol, 2010 May. PMID 20219674

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockout of the hsd11b2 Gene Extends the Cortisol Stress Response in Both Zebrafish Larvae and Adults.
    Title: Knockout of the hsd11b2 Gene Extends the Cortisol Stress Response in Both Zebrafish Larvae and Adults.
  2. Our experiments show that 20b-HSD type 2, together with 11b-HSD type 2, represents a short pathway in zebrafish to rapidly inactivate and excrete cortisol. Therefore, 20beta-HSD type 2 is an important enzyme in stress response
    Title: Zebrafish 20β-hydroxysteroid dehydrogenase type 2 is important for glucocorticoid catabolism in stress response.
  3. Sequence comparison revealed the presence of an alanine at position 253 on zebrafish 11beta-HSD2, corresponding to cysteine-264 in the substratebinding pocket of the human enzyme
    Title: Species-specific differences in the inhibition of human and zebrafish 11β-hydroxysteroid dehydrogenase 2 by thiram and organotins.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 11-beta-hydroxysteroid dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 11-beta-hydroxysteroid dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cortisol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cortisol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucocorticoid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organismal response to stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
11-beta-hydroxysteroid dehydrogenase type 2
Names
11-HSD type II
11-beta-HSD type II
11-beta-HSD2
11-beta-hydroxysteroid dehydrogenase type II
NAD-dependent 11-beta-hydroxysteroid dehydrogenase
corticosteroid 11-beta-dehydrogenase isozyme 2
NP_997885.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212720.2 → NP_997885.2  11-beta-hydroxysteroid dehydrogenase type 2

    Status: PROVISIONAL

    Source sequence(s)
    BC065613
    UniProtKB/Swiss-Prot
    F1QLP1, Q6P0H9
    Related
    ENSDARP00000118501.1, ENSDART00000141211.2
    Conserved Domains (2) summary
    cd09805
    Location:86 → 366
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
    pfam00106
    Location:86 → 279
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    35112052..35126343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1QLP1.1 GenPept UniProtKB/Swiss-Prot:F1QLP1

Gene LinkOut

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