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mapre1a microtubule-associated protein, RP/EB family, member 1a [ Danio rerio (zebrafish) ]

Gene ID: 334135, updated on 25-Apr-2024

Summary

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Official Symbol
mapre1aprovided by ZNC
Official Full Name
microtubule-associated protein, RP/EB family, member 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6067
See related
Ensembl:ENSDARG00000042927 AllianceGenome:ZFIN:ZDB-GENE-030131-6067
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
MAPRE1; mapre1l; zgc:55428; zgc:77807; wu:fi33c06
Summary
Predicted to enable microtubule plus-end binding activity. Predicted to be involved in protein localization to microtubule plus-end; regulation of microtubule polymerization or depolymerization; and spindle assembly. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm and microtubule. Predicted to be active in microtubule cytoskeleton. Orthologous to human MAPRE1 (microtubule associated protein RP/EB family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See mapre1a in Genome Data Viewer
Location:
chromosome: 8
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (23381955..23388641)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (23360716..23367402)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene nucleolar protein 4-like a Neighboring gene DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a Neighboring gene si:dkey-16n15.3 Neighboring gene si:dkey-16n15.6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comprehensive Transcriptome Analysis Reveals Sex-Specific Alternative Splicing Events in Zebrafish Gonads. Lin X, et al. Life (Basel), 2022 Sep 16. PMID 36143477, Free PMC Article
  2. Targeting the Microtubule EB1-CLASP2 Complex Modulates Na(V)1.5 at Intercalated Discs. Marchal GA, et al. Circ Res, 2021 Jul 23. PMID 34092082, Free PMC Article
  3. Developmental remodelling of non-CG methylation at satellite DNA repeats. Ross SE, et al. Nucleic Acids Res, 2020 Dec 16. PMID 33271598, Free PMC Article
  4. Analyses of mRNA structure dynamics identify embryonic gene regulatory programs. Beaudoin JD, et al. Nat Struct Mol Biol, 2018 Aug. PMID 30061596, Free PMC Article
  5. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
microtubule-associated protein RP/EB family member 1a
Names
microtubule-associated protein, RP/EB family, member 1, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282033.1 → NP_001268962.1  microtubule-associated protein RP/EB family member 1a isoform 2

    See identical proteins and their annotated locations for NP_001268962.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    BC065871, CV103612
    UniProtKB/TrEMBL
    A0A8M1P5E8, Q6P020
    Related
    ENSDARP00000068730.5, ENSDART00000074241.7
    Conserved Domains (2) summary
    pfam00307
    Location:16 → 114
    CH; Calponin homology (CH) domain
    pfam03271
    Location:203 → 240
    EB1; EB1-like C-terminal motif

  2. NM_199864.2 → NP_956158.2  microtubule-associated protein RP/EB family member 1a isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    BC065871, CV103612, EH547703
    UniProtKB/TrEMBL
    A0A8M1PDK9, B0S585, E7F5C5
    Related
    ENSDARP00000063009.4, ENSDART00000063010.6
    Conserved Domains (2) summary
    pfam00307
    Location:16 → 114
    CH; Calponin homology (CH) domain
    pfam03271
    Location:217 → 254
    EB1; EB1-like C-terminal motif

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    23381955..23388641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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