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CG40160 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3354965, updated on 10-May-2024

Summary

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Official Symbol
CG40160provided by FlyBase
Primary source
FLYBASE:FBgn0058160
Locus tag
Dmel_CG40160
See related
AllianceGenome:FB:FBgn0058160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD13269; cSPH242; Dmel\CG40160
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in extracellular region. Orthologous to human TPSAB1 (tryptase alpha/beta 1) and TPSD1 (tryptase delta 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG40160 in Genome Data Viewer
Location:
80F9-80F9; 3-47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (26215815..26229433)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3LHet NW_001848857.1 (1562357..1575983)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene lethal (3) 80Fg Neighboring gene antisense RNA:CR45182 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alkaline Ceramidase Mediates the Oxidative Stress Response in Drosophila melanogaster Through Sphingosine. Zhang CH, et al. J Insect Sci, 2019 May 1. PMID 31115476, Free PMC Article
  2. Genetic and Molecular Analysis of Essential Genes in Centromeric Heterochromatin of the Left Arm of Chromosome 3 in Drosophila melanogaster. Syrzycka M, et al. G3 (Bethesda), 2019 May 7. PMID 30948422, Free PMC Article
  3. The Drosophila Tis11 protein and its effects on mRNA expression in flies. Choi YJ, et al. J Biol Chem, 2014 Dec 19. PMID 25342740, Free PMC Article
  4. Proteomic analysis of the Drosophila larval hemolymph clot. Karlsson C, et al. J Biol Chem, 2004 Dec 10. PMID 15466469
  5. The Organization of Pericentromeric Heterochromatin in Polytene Chromosome 3 of the Drosophilamelanogaster Line with the Rif1(1); SuUR(ES) Su(var)3-9(06) Mutations Suppressing Underreplication. Zykova T, et al. Cells, 2021 Oct 20. PMID 34831030, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two clip-domain serine protease homologs, cSPH35 and cSPH242, act as a cofactor for prophenoloxidase-1 activation in Drosophila melanogaster.
    Title: Two clip-domain serine protease homologs, cSPH35 and cSPH242, act as a cofactor for prophenoloxidase-1 activation in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables serine-type endopeptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in melanization defense response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in zymogen activation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG40160-PA
CG40160-PD
CG40160-PE
CG40160-PF
CG40160-PG
CG40160-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    26215815..26229433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276236.1 → NP_001263165.1  uncharacterized protein Dmel_CG40160, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263165.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8Y546, Q95RS6
    Conserved Domains (2) summary
    smart00020
    Location:169 → 405
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:166 → 408
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_001170384.1 → NP_001163855.1  uncharacterized protein Dmel_CG40160, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163855.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8Y546, Q95RS6
    Conserved Domains (2) summary
    smart00020
    Location:169 → 405
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:166 → 408
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. NM_001015212.4 → NP_001015212.1  uncharacterized protein Dmel_CG40160, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015212.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8Y546, Q95RS6
    Conserved Domains (2) summary
    smart00020
    Location:169 → 405
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:166 → 408
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  4. NM_001170385.2 → NP_001163856.1  uncharacterized protein Dmel_CG40160, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163856.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8Y546, Q95RS6
    Conserved Domains (2) summary
    smart00020
    Location:169 → 405
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:166 → 408
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  5. NM_001015213.4 → NP_001015213.3  uncharacterized protein Dmel_CG40160, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015213.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8Y546, Q95RS6
    Conserved Domains (2) summary
    smart00020
    Location:169 → 405
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:166 → 408
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  6. NM_001015214.4 → NP_001015214.1  uncharacterized protein Dmel_CG40160, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015214.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8Y546, Q95RS6
    Conserved Domains (2) summary
    smart00020
    Location:169 → 405
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:166 → 408
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95RS6 Q95RS6

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