nrarpb NOTCH regulated ankyrin repeat protein b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nrarpbprovided by ZNC
Official Full Name: NOTCH regulated ankyrin repeat protein bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030515-7
See related: Ensembl:ENSDARG00000018958 AllianceGenome:ZFIN:ZDB-GENE-030515-7
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Nrarp-b; zgc:101875
Summary: Involved in branching involved in blood vessel morphogenesis; regulation of cell-cell adhesion; and sprouting angiogenesis. Acts upstream of or within blood vessel endothelial cell proliferation involved in sprouting angiogenesis. Is expressed in central nervous system; neural plate; neural rod; neural tube; and segmental plate. Orthologous to human NRARP (NOTCH regulated ankyrin repeat protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (66025336..66028692, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (65343540..65349638, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that the Notch-regulated ankyrin repeat protein (Nrarp) acts as a molecular link between Notch- and Lef1-dependent Wnt signaling in endothelial cells to control stability of new vessel connections in mouse and zebrafish.
Title: Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in blood vessel morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: notch-regulated ankyrin repeat-containing protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181496.5 → NP_852473.1 notch-regulated ankyrin repeat-containing protein B

See identical proteins and their annotated locations for NP_852473.1

Status: PROVISIONAL

Source sequence(s)

AF509781

UniProtKB/Swiss-Prot

Q7T3X9

UniProtKB/TrEMBL

B2GQY1

Related

ENSDARP00000003601.8, ENSDART00000022625.10

Conserved Domains (3) summary

cd00204
Location:18 → 101

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13637
Location:50 → 101

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:47 → 78

ANK; ANK repeat [structural motif]