oprk1 opioid receptor, kappa 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: oprk1provided by ZNC
Official Full Name: opioid receptor, kappa 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030729-1
See related: Ensembl:ENSDARG00000006894 AllianceGenome:ZFIN:ZDB-GENE-030729-1
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ZFOR3; ZfKOR
Summary: This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (30878073..30887209)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (30895053..30903240)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZFOR3 is a unique model to study kappa opioid receptor functionality
Title: New kappa opioid receptor from zebrafish Danio rerio.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled opioid receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables dynorphin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within behavior	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kappa-type opioid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001318780.1 → NP_001305709.1 kappa-type opioid receptor isoform 1x

Status: REVIEWED

Description

Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.

Source sequence(s)

AF285173, BC162455

UniProtKB/TrEMBL

A0A8M1P7D3, Q98U14

Conserved Domains (2) summary

pfam00001
Location:72 → 324

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:67 → 264

7tm_4; Olfactory receptor
NM_182886.2 → NP_878306.2 kappa-type opioid receptor isoform 1

Status: REVIEWED

Description

Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).

Source sequence(s)

AF285173, BC162455

UniProtKB/TrEMBL

A0A8M1PCB9, B3DGN0, Q98U14

Related

ENSDARP00000022783.4, ENSDART00000009326.5

Conserved Domains (2) summary

pfam00001
Location:72 → 324

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:67 → 264

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

30878073..30887209

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163421.4 → XP_005163478.1 kappa-type opioid receptor isoform X1

UniProtKB/TrEMBL

A0A8M2BAU5, Q98U14

Conserved Domains (2) summary

pfam00001
Location:129 → 381

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:124 → 321

7tm_4; Olfactory receptor