Ccz1 CCZ1 homolog, vacuolar protein trafficking and biogenesis associated [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccz1provided by RGD
Official Full Name: CCZ1 homolog, vacuolar protein trafficking and biogenesis associatedprovided by RGD
Primary source: RGD:1306410
See related: Ensembl:ENSRNOG00000001032 AllianceGenome:RGD:1306410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ccz1b; RGD1306410
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in lysosomal membrane. Predicted to be part of Mon1-Ccz1 complex. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to several human genes including CCZ1 (CCZ1 homolog, vacuolar protein trafficking and biogenesis associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 174.2), Spleen (RPKM 157.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (15714768..15738273)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (10601066..10624608)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (12638849..12662371)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131271 (e-PCR)
- UniSTS:214554

BE110334 (e-PCR)
- UniSTS:245243

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Mon1-Ccz1 complex	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vacuolar fusion protein CCZ1 homolog

Names: CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated; CCZ1 homolog, vacuolar protein trafficking and biogenesis associated B; CCZ1 vacuolar protein trafficking and biogenesis associated homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001394280.1 → NP_001381209.1 vacuolar fusion protein CCZ1 homolog isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A0G2JUB1, A0A140UHX9

Related

ENSRNOP00000001365.6, ENSRNOT00000001365.8

Conserved Domains (1) summary

pfam08217
Location:25 → 477

DUF1712; Fungal domain of unknown function (DUF1712)
NM_001394281.1 → NP_001381210.1 vacuolar fusion protein CCZ1 homolog isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

Conserved Domains (1) summary

pfam08217
Location:25 → 424

DUF1712; Fungal domain of unknown function (DUF1712)