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Lgi4 leucine-rich repeat LGI family, member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361549, updated on 3-Apr-2024

Summary

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Official Symbol
Lgi4provided by RGD
Official Full Name
leucine-rich repeat LGI family, member 4provided by RGD
Primary source
RGD:735035
See related
Ensembl:ENSRNOG00000021087 AllianceGenome:RGD:735035
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in myelination in peripheral nervous system; neuron maturation; and regulation of myelination. Predicted to act upstream of or within adult locomotory behavior; gliogenesis; and myelination. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-1 and childhood absence epilepsy. Orthologous to human LGI4 (leucine rich repeat LGI family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 100.1), Heart (RPKM 27.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95422461..95433296)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86294539..86305909)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89491588..89502939)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene FXYD domain-containing ion transport regulator 7 Neighboring gene FXYD domain-containing ion transport regulator 1 Neighboring gene FXYD domain-containing ion transport regulator 3 Neighboring gene uncharacterized LOC134483096 Neighboring gene hepsin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Loss-of-Function Mutations in LGI4, a Secreted Ligand Involved in Schwann Cell Myelination, Are Responsible for Arthrogryposis Multiplex Congenita. Xue S, et al. Am J Hum Genet, 2017 Apr 6. PMID 28318499, Free PMC Article
  2. Genotypic association of exonic LGI4 polymorphisms and childhood absence epilepsy. Gu W, et al. Neurogenetics, 2004 Feb. PMID 14505228
  3. The mouse mutation claw paw: forelimb deformity and delayed myelination throughout the peripheral nervous system. Henry EW, et al. J Hered, 1991 Jul-Aug. PMID 1652607
  4. The effect of the mouse mutation claw paw on myelination and nodal frequency in sciatic nerves. Koszowski AG, et al. J Neurosci, 1998 Aug 1. PMID 9671673, Free PMC Article
  5. Cell autonomy of the mouse claw paw mutation. Darbas A, et al. Dev Biol, 2004 Aug 15. PMID 15282162

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within Schwann cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glial cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gliogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in myelination in peripheral nervous system IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within myelination in peripheral nervous system ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of myelination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine-rich repeat LGI family member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199499.1 → NP_955793.1  leucine-rich repeat LGI family member 4 precursor

    See identical proteins and their annotated locations for NP_955793.1

    Status: PROVISIONAL

    Source sequence(s)
    BC064659
    UniProtKB/TrEMBL
    A0A8I5ZQZ4, F7FDT1, Q6P2A4
    Related
    ENSRNOP00000028632.3, ENSRNOT00000028632.6
    Conserved Domains (5) summary
    smart00082
    Location:158 → 207
    LRRCT; Leucine rich repeat C-terminal domain
    sd00031
    Location:54 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam03736
    Location:396 → 438
    EPTP; EPTP domain
    pfam12799
    Location:102 → 140
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:76 → 136
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    95422461..95433296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266499.1 → XP_063122569.1  leucine-rich repeat LGI family member 4 isoform X1

  2. XM_039081997.1 → XP_038937925.1  leucine-rich repeat LGI family member 4 isoform X2

    Conserved Domains (1) summary
    pfam03736
    Location:162 → 202
    EPTP; EPTP domain

  3. XM_039082002.1 → XP_038937930.1  leucine-rich repeat LGI family member 4 isoform X2

    Conserved Domains (1) summary
    pfam03736
    Location:162 → 202
    EPTP; EPTP domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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