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Kank3 KN motif and ankyrin repeat domains 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366848, updated on 5-Mar-2024

Summary

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Official Symbol
Kank3provided by RGD
Official Full Name
KN motif and ankyrin repeat domains 3provided by RGD
Primary source
RGD:1308853
See related
Ensembl:ENSRNOG00000007230 AllianceGenome:RGD:1308853
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ankrd47; RGD1308853
Summary
Predicted to be involved in negative regulation of actin filament polymerization. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human KANK3 (KN motif and ankyrin repeat domains 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 262.6), Testes (RPKM 130.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kank3 in Genome Data Viewer
Location:
7q13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (15296538..15309838)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (14594358..14607675)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (18668665..18681945)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene angiopoietin-like 4 Neighboring gene uncharacterized LOC134479827 Neighboring gene ribosomal protein S28 Neighboring gene NADH:ubiquinone oxidoreductase subunit A7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
KN motif and ankyrin repeat domain-containing protein 3
Names
ankyrin repeat domain 47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108989.1 → NP_001102459.1  KN motif and ankyrin repeat domain-containing protein 3

    See identical proteins and their annotated locations for NP_001102459.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474088
    UniProtKB/TrEMBL
    A0A8I6AQY0, B2RYN8
    Related
    ENSRNOP00000096794.1, ENSRNOT00000120241.1
    Conserved Domains (5) summary
    cd00204
    Location:610 → 742
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12075
    Location:32 → 73
    KN_motif; KN motif
    pfam12796
    Location:654 → 753
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:604 → 657
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:615 → 647
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    15296538..15309838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079670.2 → XP_038935598.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X2

    Conserved Domains (1) summary
    pfam12075
    Location:32 → 73
    KN_motif; KN motif

  2. XM_039079671.2 → XP_038935599.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X3

    Conserved Domains (1) summary
    pfam12075
    Location:32 → 73
    KN_motif; KN motif

  3. XM_008765202.3 → XP_008763424.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQY0, F7FCJ4
    Related
    ENSRNOP00000009532.6
    Conserved Domains (5) summary
    cd00204
    Location:620 → 752
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12075
    Location:32 → 73
    KN_motif; KN motif
    pfam12796
    Location:664 → 763
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:614 → 667
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:625 → 657
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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