mvp major vault protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mvpprovided by ZNC
Official Full Name: major vault proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030826-33
See related: Ensembl:ENSDARG00000021242 AllianceGenome:ZFIN:ZDB-GENE-030826-33
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb771; wu:fb52b05; wu:fc02g01
Summary: Acts upstream of or within brain development; eye development; and neuron projection regeneration. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; hatching gland; nervous system; periderm; and polster. Human ortholog(s) of this gene implicated in mitral valve prolapse. Orthologous to human MVP (major vault protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (15708371..15734525, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (15558572..15584725, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MVP is a negative regulator of IFN production by restricting the activation of TBK1
Title: Zebrafish MVP Recruits and Degrades TBK1 To Suppress IFN Production.
MVP is beneficial for functional recovery and axonal regrowth after spinal cord injury in adult zebrafish.
Title: Major vault protein promotes locomotor recovery and regeneration after spinal cord injury in adult zebrafish.

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General gene information

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Markers

fb52b05.x1 (e-PCR)
- UniSTS:203279

fc02g01.x1 (e-PCR)
- UniSTS:203678

fd19c12.x1 (e-PCR)
- UniSTS:195242

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: major vault protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201325.2 → NP_958482.1 major vault protein

See identical proteins and their annotated locations for NP_958482.1

Status: VALIDATED

Source sequence(s)

BX936308

UniProtKB/Swiss-Prot

Q6P3L0, Q7ZUB4

Related

ENSDARP00000115387.1, ENSDART00000137325.3

Conserved Domains (6) summary

PTZ00491
Location:10 → 859

PTZ00491; major vault protein; Provisional

cd08825
Location:523 → 674

MVP_shoulder; Shoulder domain of the major vault protein

pfam01505
Location:118 → 157

Vault; Major Vault Protein repeat

cd16269
Location:802 → 814

GBP_C; coiled coil [structural motif]

cl19107
Location:626 → 754

SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

cl20817
Location:703 → 827

GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

15708371..15734525 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163803.4 → XP_005163860.1 major vault protein isoform X1

UniProtKB/TrEMBL

A0A8M2BB27, E9QEQ6

Related

ENSDARP00000112736.1, ENSDART00000141142.2

Conserved Domains (6) summary

PTZ00491
Location:16 → 866

PTZ00491; major vault protein; Provisional

cd08825
Location:530 → 681

MVP_shoulder; Shoulder domain of the major vault protein

pfam01505
Location:124 → 163

Vault; Major Vault Protein repeat

cd16269
Location:809 → 821

GBP_C; coiled coil [structural motif]

cl19107
Location:633 → 761

SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

cl20817
Location:710 → 834

GBP_C; Guanylate-binding protein, C-terminal domain