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ankrd6b ankyrin repeat domain 6b [ Danio rerio (zebrafish) ]

Gene ID: 378477, updated on 27-Mar-2024

Summary

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Official Symbol
ankrd6bprovided by ZNC
Official Full Name
ankyrin repeat domain 6bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030916-4
See related
Ensembl:ENSDARG00000029370 AllianceGenome:ZFIN:ZDB-GENE-030916-4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ankrd6; diversin; si:dkey-181i3none
Summary
Acts upstream of or within several processes, including determination of ventral identity; gastrulation; and regulation of signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in liver. Orthologous to human ANKRD6 (ankyrin repeat domain 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See ankrd6b in Genome Data Viewer
Location:
chromosome: 20
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (1203579..1239682, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (1182637..1218894, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909286 Neighboring gene LYR motif containing 2 Neighboring gene large tumor suppressor kinase 1 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification and characterization of rat Ankrd6 gene in silico. Katoh M, et al. Int J Mol Med, 2005 Feb. PMID 15647854
  2. Initiation of synapse formation by Wnt-induced MuSK endocytosis. Gordon LR, et al. Development, 2012 Mar. PMID 22318632, Free PMC Article
  3. Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. Brembeck FH, et al. Genes Dev, 2004 Sep 15. PMID 15371335, Free PMC Article
  4. Exome Sequence Analysis Suggests that Genetic Burden Contributes to Phenotypic Variability and Complex Neuropathy. Gonzaga-Jauregui C, et al. Cell Rep, 2015 Aug 18. PMID 26257172, Free PMC Article
  5. Diversin regulates heart formation and gastrulation movements in development. Moeller H, et al. Proc Natl Acad Sci U S A, 2006 Oct 24. PMID 17032765, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to beta-catenin binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of ventral identity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of beta-catenin destruction complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 6; ankyrin repeat domain-containing protein 6b
Names
ankyrin repeat domain 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194423.2 → NP_919404.2  ankyrin repeat domain-containing protein 6b

    Status: VALIDATED

    Source sequence(s)
    BX248418, EB936847
    UniProtKB/TrEMBL
    A0A8M1PB29, F6NJE0
    Related
    ENSDARP00000118157.1, ENSDART00000140650.3
    Conserved Domains (5) summary
    cd00204
    Location:39 → 163
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06640
    Location:498 → 593
    P_C; P protein C-terminus
    pfam12796
    Location:48 → 140
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:16 → 64
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:43 → 74
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    1203579..1239682 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468372.1 → XP_021324047.1  ankyrin repeat domain-containing protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8M9P2G9
    Conserved Domains (4) summary
    cd00204
    Location:65 → 185
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:65 → 96
    ANK; ANK repeat [structural motif]
    cl26072
    Location:214 → 293
    Ank_5; Ankyrin repeats (many copies)
    cl26386
    Location:554 → 721
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
Nucleotide Protein Strain
Heading Accession and Version

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