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scd stearoyl-CoA desaturase (delta-9-desaturase) [ Danio rerio (zebrafish) ]

Gene ID: 386661, updated on 5-May-2024

Summary

Official Symbol
scdprovided by ZNC
Official Full Name
stearoyl-CoA desaturase (delta-9-desaturase)provided by ZNC
Primary source
ZFIN:ZDB-GENE-031106-3
See related
Ensembl:ENSDARG00000033662 AllianceGenome:ZFIN:ZDB-GENE-031106-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
SCD1
Summary
Predicted to enable iron ion binding activity; palmitoyl-CoA 9-desaturase activity; and stearoyl-CoA 9-desaturase activity. Predicted to be involved in monounsaturated fatty acid biosynthetic process; response to fatty acid; and unsaturated fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in brain; female organism; heart; liver; and muscle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to human SCD (stearoyl-CoA desaturase) and SCD5 (stearoyl-CoA desaturase 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See scd in Genome Data Viewer
Location:
chromosome: 12
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (48390713..48406198)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (48407391..48422876)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene DNA-damage-inducible transcript 4 Neighboring gene DnaJ heat shock protein family (Hsp40) member B12b Neighboring gene SEC31 homolog B, COPII coat complex component Neighboring gene NADH:ubiquinone oxidoreductase subunit B8

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables stearoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables stearoyl-CoA 9-desaturase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within fat pad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in monounsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within swimming behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in unsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acyl-CoA desaturase
NP_942110.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198815.2NP_942110.2  acyl-CoA desaturase

    Status: VALIDATED

    Source sequence(s)
    FP102054
    UniProtKB/TrEMBL
    A0A8M1P985, F1QG70
    Related
    ENSDARP00000124185.1, ENSDART00000149351.2
    Conserved Domains (2) summary
    cd03505
    Location:64304
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
    pfam00487
    Location:68273
    FA_desaturase; Fatty acid desaturase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    48390713..48406198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)