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Pcdha7 protocadherin alpha 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 393089, updated on 24-Oct-2023

Summary

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Symbol
Pcdha7provided by RGD
Full Name
protocadherin alpha 7provided by RGD
Primary source
RGD:735055
See related
AllianceGenome:RGD:735055
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
rCNRv07
Summary
Predicted to enable calcium ion binding activity and identical protein binding activity. Predicted to be involved in cell-cell recognition and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Orthologous to human PCDHA7 (protocadherin alpha 7). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
not in current annotation release
Expression
Biased expression in Brain (RPKM 151.9), Lung (RPKM 105.9) and 8 other tissues See more
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Genomic context

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See Pcdha7 in Genome Data Viewer
Location:
18p11

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins. Goodman KM, et al. Neuron, 2016 May 18. PMID 27161523, Free PMC Article
  2. Genomic sequence and organization of the family of CNR/Pcdhalpha genes in rat. Yanase H, et al. Genomics, 2004 Apr. PMID 15028293
  3. Sequence analysis and expression mapping of the rat clustered protocadherin gene repertoires. Zou C, et al. Neuroscience, 2007 Jan 19. PMID 17110050
  4. Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha. Murata Y, et al. J Biol Chem, 2004 Nov 19. PMID 15347688
  5. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, et al. Genome Res, 2004 Jan. PMID 14672974, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell-cell recognition ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protocadherin alpha-7
Names
cadherin-related neuronal receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199507.1 → NP_955801.1  protocadherin alpha-7 precursor

    See identical proteins and their annotated locations for NP_955801.1

    Status: PROVISIONAL

    Source sequence(s)
    AB113390
    UniProtKB/TrEMBL
    M0RB51, Q767I5
    Conserved Domains (3) summary
    cd11304
    Location:247 → 346
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:30 → 111
    Cadherin_2; Cadherin-like
    pfam15974
    Location:786 → 929
    Cadherin_tail; Cadherin C-terminal cytoplasmic tail, catenin-binding region
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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