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c6 complement component 6 [ Danio rerio (zebrafish) ]

Gene ID: 393611, updated on 6-Jun-2024

Summary

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Official Symbol
c6provided by ZNC
Official Full Name
complement component 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1358
See related
Ensembl:ENSDARG00000057113 AllianceGenome:ZFIN:ZDB-GENE-040426-1358
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:64073
Summary
Predicted to act upstream of or within complement activation, classical pathway; cytolysis; and innate immune response. Predicted to be located in extracellular region. Predicted to be part of membrane attack complex. Is expressed in epidermis; gut; liver; periderm; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in complement component 6 deficiency. Orthologous to human C6 (complement C6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (20915456..20932729, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (20878823..20896084, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial-like Neighboring gene complement component 7b Neighboring gene regulator of G protein signaling 7 binding protein b Neighboring gene ring finger protein 180b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification and functional analysis of the perforin-1 like gene in disease resistance in half smooth tongue sole (Cynoglossus semilaevis). Fu X, et al. Dev Comp Immunol, 2021 Sep. PMID 34004267
  2. Response of complement expression to challenge with lipopolysaccharide in embryos/larvae of zebrafish Danio rerio: acquisition of immunocompetent complement. Wang Z, et al. Fish Shellfish Immunol, 2008 Sep. PMID 18657447
  3. Fish complement C8 evolution, functional network analyses, and the theoretical interaction between C8 alpha chain and CD59. Li L, et al. Mol Immunol, 2020 Dec. PMID 33160183
  4. Xirp proteins mark injured skeletal muscle in zebrafish. Otten C, et al. PLoS One, 2012. PMID 22355335, Free PMC Article
  5. Differential transcriptome analysis of zebrafish (Danio rerio) larvae challenged by Vibrio parahaemolyticus. Zhang Q, et al. J Fish Dis, 2018 Jul. PMID 29572872

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC64073

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in complement activation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of membrane attack complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of membrane attack complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
complement component C6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200638.1 → NP_956932.1  complement component C6

    See identical proteins and their annotated locations for NP_956932.1

    Status: PROVISIONAL

    Source sequence(s)
    BC057429
    UniProtKB/TrEMBL
    A0A0R4IXC5, A0A8N7XIZ7, F6NHD3, Q6PFT2
    Related
    ENSDARP00000074161.3, ENSDART00000079709.4
    Conserved Domains (5) summary
    cd00033
    Location:594 → 650
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00057
    Location:813 → 883
    FIMAC; factor I membrane attack complex
    smart00209
    Location:517 → 561
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:123 → 154
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:248 → 463
    MACPF; MAC/Perforin domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    20915456..20932729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161159.4 → XP_005161216.1  complement component C6 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B830
    Conserved Domains (5) summary
    cd00033
    Location:614 → 670
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00057
    Location:768 → 838
    FIMAC; factor I membrane attack complex
    smart00209
    Location:537 → 581
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:143 → 174
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:268 → 483
    MACPF; MAC/Perforin domain

  2. XM_005161158.4 → XP_005161215.1  complement component C6 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B846
    Conserved Domains (5) summary
    cd00033
    Location:614 → 670
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00057
    Location:833 → 903
    FIMAC; factor I membrane attack complex
    smart00209
    Location:537 → 581
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:143 → 174
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:268 → 483
    MACPF; MAC/Perforin domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395089.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    90744..107888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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