dctpp1 dCTP pyrophosphatase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dctpp1provided by ZNC
Official Full Name: dCTP pyrophosphatase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1741
See related: Ensembl:ENSDARG00000054334 AllianceGenome:ZFIN:ZDB-GENE-040426-1741
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gatb; pet112; zgc:73273
Summary: Predicted to enable dCTP diphosphatase activity. Predicted to be involved in DNA protection and dCTP catabolic process. Predicted to act upstream of or within nucleoside triphosphate catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including immature eye; midbrain; neural plate; neural tube; and spinal cord. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 41. Orthologous to several human genes including DCTPP1 (dCTP pyrophosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (24557414..24558749)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (23866585..23867920)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dCTP diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dCTP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate diphosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA protection	IBA Inferred from Biological aspect of Ancestor more info
involved_in dCTP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nucleoside triphosphate catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

Names: cytochrome c oxidase assembly factor PET112 homolog

NP_957065.1

EC 3.6.1.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200771.1 → NP_957065.1 glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

See identical proteins and their annotated locations for NP_957065.1

Status: PROVISIONAL

Source sequence(s)

BC059602

UniProtKB/TrEMBL

A8KBR4, Q7T009

Related

ENSDARP00000070991.3, ENSDART00000076519.5

Conserved Domains (1) summary

cd11537
Location:52 → 142

NTP-PPase_RS21-C6_like; Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs