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CTSC cathepsin C [ Canis lupus familiaris (dog) ]

Gene ID: 403458, updated on 5-Mar-2024

Summary

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Official Symbol
CTSCprovided by VGNC
Official Full Name
cathepsin Cprovided by VGNC
Primary source
VGNC:VGNC:111424
See related
Ensembl:ENSCAFG00845026305
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
DPPI; DPP-I
Orthologs
human mouse all
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Genomic context

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See CTSC in Genome Data Viewer
Location:
chromosome: 21
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (11838431..11874146)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (11517038..11552914)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (11752070..11787980)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (11627285..11662982)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (11697940..11733812)

Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119864956 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC111091494 Neighboring gene RAB38, member RAS oncogene family Neighboring gene uncharacterized LOC111091495

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulated expression, processing, and secretion of dog mast cell dipeptidyl peptidase I. Wolters PJ, et al. J Biol Chem, 1998 Jun 19. PMID 9624139

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dipeptidyl peptidase 1
Names
cathepsin J
dipeptidyl peptidase I
dipeptidyl transferase
NP_001182763.1
XP_038285360.1
XP_038285361.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195834.1 → NP_001182763.1  dipeptidyl peptidase 1 precursor

    Status: PROVISIONAL

    Source sequence(s)
    AF060171, GR899188
    UniProtKB/TrEMBL
    A0A8I3NYF4
    Related
    ENSCAFP00845036469.1, ENSCAFT00845046453.1
    Conserved Domains (2) summary
    cd02621
    Location:228 → 456
    Peptidase_C1A_CathepsinC; Cathepsin C; also known as Dipeptidyl Peptidase I (DPPI), an atypical papain-like cysteine peptidase with chloride dependency and dipeptidyl aminopeptidase activity, resulting from its tetrameric structure which limits substrate access. Each subunit of ...
    pfam08773
    Location:26 → 137
    CathepsinC_exc; Cathepsin C exclusion domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051825.1 Reference ROS_Cfam_1.0

    Range
    11838431..11874146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038429432.1 → XP_038285360.1  dipeptidyl peptidase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0TBY6
    Conserved Domains (1) summary
    pfam08773
    Location:25 → 105
    CathepsinC_exc; Cathepsin C exclusion domain

  2. XM_038429433.1 → XP_038285361.1  dipeptidyl peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KZS6, A0A8C0TBY6
    Related
    ENSCAFP00845036428.1, ENSCAFT00845046390.1
    Conserved Domains (1) summary
    pfam08773
    Location:25 → 105
    CathepsinC_exc; Cathepsin C exclusion domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049281.1 Alternate UMICH_Zoey_3.1

    Range
    11627285..11662982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

    Range
    11697940..11733812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

    Range
    11752070..11787980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    11517038..11552914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O97578.1 GenPept UniProtKB/Swiss-Prot:O97578

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