U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 [ Canis lupus familiaris (dog) ]

Gene ID: 403992, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ATP1A1provided by VGNC
Official Full Name
ATPase Na+/K+ transporting subunit alpha 1provided by VGNC
Primary source
VGNC:VGNC:38245
See related
Ensembl:ENSCAFG00845028456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ATP1A1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
24
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (54699283..54728846)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (53476043..53494904)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (54356732..54375594)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (53747272..53766129)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (53783159..53802012)

Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119869814 Neighboring gene uncharacterized LOC102156859 Neighboring gene pre-mRNA-splicing regulator WTAP-like Neighboring gene uncharacterized LOC102156918 Neighboring gene CD58 molecule

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Na,K-ATPase response to osmotic stress in primary dog lens epithelial cells. Old SE, et al. Invest Ophthalmol Vis Sci, 1995 Jan. PMID 7822162
  2. Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance. Canessa CM, et al. EMBO J, 1992 May. PMID 1316269, Free PMC Article
  3. Lack of Na(+),K (+)-ATPase expression in intercalated cells may be compensated by Na(+)-ATPase: a study on MDCK - C11 cells. Sampaio MS, et al. Cell Mol Life Sci, 2008 Oct. PMID 18759127, Free PMC Article
  4. Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility. Barwe SP, et al. Mol Biol Cell, 2005 Mar. PMID 15616195, Free PMC Article
  5. Regulation of the ankyrin-B-based targeting pathway following myocardial infarction. Hund TJ, et al. Cardiovasc Res, 2009 Mar 1. PMID 19074823, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that the presence of Na(+)-ATPase in intercalated cells may explain the adequate survival of cells that lack Na(+),K(+)-ATPase.
    Title: Lack of Na(+),K (+)-ATPase expression in intercalated cells may be compensated by Na(+)-ATPase: a study on MDCK - C11 cells.
  2. Na,K-ATPase has a role in phosphatidylinositol 3-kinase signaling and suppression of cell motility
    Title: Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables P-type sodium:potassium-exchanging transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular potassium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular sodium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in potassium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion export across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
sodium/potassium-transporting ATPase subunit alpha-1
Names
ATPase, Na+/K+ transporting, alpha 1 polypeptide
Na(+)/K(+) ATPase alpha-1 subunit
sodium pump subunit alpha-1
NP_001376153.1
XP_038546393.1
XP_038546394.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389224.1 → NP_001376153.1  sodium/potassium-transporting ATPase subunit alpha-1

    Status: VALIDATED

    Source sequence(s)
    CK999890, CN001417, CO587921, DN334534, DN368491, DN442720, DN443269, DN871809, EF489486, JAAUVH010000359, L42173
    UniProtKB/TrEMBL
    A0A8C0MD48, A0A8I3QHE9
    Related
    ENSCAFP00845039830.1, ENSCAFT00845050808.1
    Conserved Domains (1) summary
    TIGR01106
    Location:1 → 992
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051821.1 Reference ROS_Cfam_1.0

    Range
    54699283..54728846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038690465.1 → XP_038546393.1  sodium/potassium-transporting ATPase subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MD48, A0A8C0SEE0, A0A8I3QH87, A0A8I3QHE9
    Related
    ENSCAFP00845039732.1, ENSCAFT00845050684.1
    Conserved Domains (1) summary
    TIGR01106
    Location:25 → 1021
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

  2. XM_038690466.1 → XP_038546394.1  sodium/potassium-transporting ATPase subunit alpha-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MD48, A0A8C0SDF3, A0A8I3Q559, A0A8I3QHE9
    Related
    ENSCAFP00845039799.1, ENSCAFT00845050767.1
    Conserved Domains (1) summary
    TIGR01106
    Location:25 → 1021
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049277.1 Alternate UMICH_Zoey_3.1

    Range
    53747272..53766129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

    Range
    53783159..53802012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

    Range
    54356732..54375594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    53476043..53494904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003306.2: Suppressed sequence

    Description
    NM_001003306.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50997.1 GenPept UniProtKB/Swiss-Prot:P50997

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous