tpm4a tropomyosin 4a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tpm4aprovided by ZNC
Official Full Name: tropomyosin 4aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2185
See related: Ensembl:ENSDARG00000023963 AllianceGenome:ZFIN:ZDB-GENE-040426-2185
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tpm4; TPM4-1; zgc:63909; wu:fb06e07; zgc:103436
Summary: Predicted to enable actin filament binding activity. Acts upstream of or within cardiac muscle contraction and cardiac myofibril assembly. Predicted to be active in actin filament. Is expressed in several structures, including cardiovascular system; head mesenchyme; mesoderm; muscle; and thymus. Orthologous to human TPM4 (tropomyosin 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (15578710..15602803, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (15552327..15576533, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos.
Title: Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tropomyosin 4a; tropomyosin alpha-4 chain

Names: tropomyosin 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.