shtn1 shootin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: shtn1provided by ZNC
Official Full Name: shootin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-121127-1
See related: Ensembl:ENSDARG00000039697 AllianceGenome:ZFIN:ZDB-GENE-121127-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: shootin1; gb:bc139653; si:ch73-56p18.4
Summary: Predicted to enable actin filament binding activity. Acts upstream of or within posterior lateral line neuromast primordium migration. Predicted to be located in several cellular components, including axonal growth cone; lamellipodium; and perikaryon. Predicted to be part of microtubule associated complex. Is expressed in neuromast and posterior lateral line primordium. Orthologous to human SHTN1 (shootin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (21311401..21368712, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (21291565..21348876, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Shootin-1 is required for nervous system development in zebrafish.
Title: Shootin-1 is required for nervous system development in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Cdc42 protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in Ras protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament bundle retrograde transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoplasmic actin-based contraction involved in cell motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum polarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in netrin-activated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of axon extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within posterior lateral line neuromast primordium migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in substrate-dependent cell migration, cell extension	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
is_active_in axonal growth cone	IBA Inferred from Biological aspect of Ancestor more info
located_in axonal growth cone	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell leading edge	IBA Inferred from Biological aspect of Ancestor more info
located_in cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
part_of microtubule associated complex	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: shootin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198761.1 → NP_001185690.1 shootin-1

See identical proteins and their annotated locations for NP_001185690.1

Status: VALIDATED

Source sequence(s)

BC115236

UniProtKB/Swiss-Prot

Q08C01, Q1RLX9, Q6P0R8

Related

ENSDARP00000058026.4, ENSDART00000058027.6

Conserved Domains (2) summary

TIGR01843
Location:144 → 286

type_I_hlyD; type I secretion membrane fusion protein, HlyD family

PRK13729
Location:290 → 345

PRK13729; conjugal transfer pilus assembly protein TraB; Provisional

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

21311401..21368712 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467139.1 → XP_021322814.1 shootin-1 isoform X1

UniProtKB/TrEMBL

A0A8M9PE57

Conserved Domains (1) summary

cl25732
Location:42 → 303

SMC_N; RecF/RecN/SMC N terminal domain