trp transient receptor potential [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: trpprovided by FlyBase
Official Full Name: transient receptor potentialprovided by FlyBase
Primary source: FLYBASE:FBgn0003861
Locus tag: Dmel_CG7875
See related: AllianceGenome:FB:FBgn0003861
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 559; CG7875; Dmel\CG7875; DmTRP; dTrp; dTRP; dTRPC1; gene B; idl-B; Trp; TRP
Summary: Enables ion channel activity and protein dimerization activity. Involved in several processes, including cellular response to anoxia; detection of visible light; and olfactory learning. Located in rhabdomere microvillus membrane. Part of cation channel complex and inaD signaling complex. Is expressed in several structures, including head and visual system. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in cerebellar ataxia type 41; chronic fatigue syndrome; focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Orthologous to several human genes including TRPC4 (transient receptor potential cation channel subfamily C member 4) and TRPC5 (transient receptor potential cation channel subfamily C member 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 99C6-99C7; 3-99 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29914521..29920289, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25740243..25746011, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calmodulin binds to Drosophila TRP with an unexpected mode.
Title: Calmodulin binds to Drosophila TRP with an unexpected mode.
Calmodulin binding could induce secondary structure changes in Drosophila TRP C-terminus.TRP 783-862 is a novel calmodulin binding site
Title: Identification and characterization of a novel calmodulin binding site in Drosophila TRP C-terminus.
results indicate that properties of the light-activated channels together with the dynamic light-dependent process of TRP phosphorylation at the S936 site determine response kinetics
Title: The latency of the light response is modulated by the phosphorylation state of Drosophila TRP at a specific site.
TRP de-phosphorylation affects the detection limit of oscillating light in photoreceptor cells.
Title: The Phosphorylation State of the Drosophila TRP Channel Modulates the Frequency Response to Oscillating Light In Vivo.
Data show that phosphorylation of most ransient receptor potential (TRP) ion channel sites depends on the phototransduction cascade and the activity of the TRP.
Title: Phosphorylation of the Drosophila transient receptor potential ion channel is regulated by the phototransduction cascade and involves several protein kinases and phosphatases.
TRP and TRPL assemble exclusively as homomultimeric channels in their native environment.
Title: Drosophila TRP and TRPL are assembled as homomultimeric channels in vivo.
These results indicate that the Pain TRP channels in the MBs and IPCs control neuronal plasticity that is required for the formation of a certain type of long-lasting associative memory in Drosophila.
Title: Significance of the centrally expressed TRP channel painless in Drosophila courtship memory.
Vesicle exocytosis depends on cacophony, TRP and TRPL.
Title: TRP, TRPL and cacophony channels mediate Ca2+ influx and exocytosis in photoreceptors axons in Drosophila.
the unitary currents from Drosophila trpl and trp photoreceptors correspond to TRP and TRPL.
Title: Unitary recordings of TRP and TRPL channels from isolated Drosophila retinal photoreceptor rhabdomeres: activation by light and lipids.
TRPL and TRP are required for cool avoidance; however they are dispensable for warm avoidance
Title: Distinct TRP channels are required for warm and cool avoidance in Drosophila melanogaster.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Dm2222 (e-PCR)
- UniSTS:10623

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables light-activated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-mediated opsin signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cellular response to anoxia	IGI Inferred from Genetic Interaction more info	PubMed
involved_in detection of light stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of light stimulus involved in visual perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inorganic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction, visible light	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retina homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cation channel complex	IPI Inferred from Physical Interaction more info	PubMed
part_of inaD signaling complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere	IMP Inferred from Mutant Phenotype more info	PubMed
located_in rhabdomere microvillus membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: transient receptor potential

Names: CG7875-PA; CG7875-PB; Cosens-Manning mutant; INAD localization-B; transient photreceptor potential; transient receptor potential protein; trp-PA; trp-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

29914521..29920289 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057420.4 → NP_476768.1 transient receptor potential, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476768.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P19334, Q7YU76, Q9VAE1

UniProtKB/TrEMBL

F0JAI0, U3PXB8

Related

FBpp0084879

Conserved Domains (5) summary

cd00204
Location:64 → 168

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:16 → 776

trp; transient-receptor-potential calcium channel protein

pfam05466
Location:938 → 1158

BASP1; Brain acid soluble protein 1 (BASP1 protein)

pfam08344
Location:178 → 236

TRP_2; Transient receptor ion channel II

sd00045
Location:69 → 98

ANK; ANK repeat [structural motif]
NM_001276161.1 → NP_001263090.1 transient receptor potential, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263090.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHH9

Conserved Domains (5) summary

cd00204
Location:64 → 168

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08344
Location:178 → 236

TRP_2; Transient receptor ion channel II

pfam12796
Location:74 → 168

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:40 → 90

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:69 → 98

ANK; ANK repeat [structural motif]