PRDX5 peroxiredoxin 5 [Canis lupus familiaris (dog)] - Gene

Summary

Gene symbol: PRDX5
Gene description: peroxiredoxin 5
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	18	NC_051822.1 (53796390..53800034, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	18	NC_006600.4 (51358049..51361693, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	18	NC_049239.1 (53258704..53262348, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	18	NC_049278.1 (52888242..52891882, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	18	NC_049759.1 (52474829..52478470, complement)

Chromosome 18 - NC_051822.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

basal expression of the human PRDX5 gene is regulated by GABP
Title: Transcription factor GABP/NRF-2 controlling biogenesis of mitochondria regulates basal expression of peroxiredoxin V but the mitochondrial function of peroxiredoxin V is dispensable in the dog.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables thioredoxin peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: peroxiredoxin-5, mitochondrial

XP_038281094.1

EC 1.11.1.24

EC 1.11.1.7

XP_038281095.1

EC 1.11.1.24

EC 1.11.1.7

XP_038281096.1

EC 1.11.1.24

EC 1.11.1.7

XP_038309729.1

EC 1.11.1.24

EC 1.11.1.7

XP_038309731.1

EC 1.11.1.24

EC 1.11.1.7

XP_038357355.1

EC 1.11.1.24

EC 1.11.1.7

XP_038357356.1

EC 1.11.1.24

EC 1.11.1.7

XP_038357357.1

EC 1.11.1.24

EC 1.11.1.7

XP_038420040.1

EC 1.11.1.24

EC 1.11.1.7

XP_038420041.1

EC 1.11.1.24

EC 1.11.1.7

XP_038420042.1

EC 1.11.1.24

EC 1.11.1.7

XP_038484193.1

EC 1.11.1.24

EC 1.11.1.7

XP_038484194.1

EC 1.11.1.24

EC 1.11.1.7

XP_038484195.1

EC 1.11.1.24

EC 1.11.1.7

XP_533241.5

EC 1.11.1.24

EC 1.11.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051822.1 Reference ROS_Cfam_1.0

Range

53796390..53800034 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038425166.1 → XP_038281094.1 peroxiredoxin-5, mitochondrial isoform X1

Conserved Domains (1) summary

cd03013
Location:20 → 174

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
XM_038425168.1 → XP_038281096.1 peroxiredoxin-5, mitochondrial isoform X3

Conserved Domains (1) summary

cd03013
Location:6 → 160

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
XM_038425167.1 → XP_038281095.1 peroxiredoxin-5, mitochondrial isoform X2

Conserved Domains (1) summary

cd03013
Location:16 → 170

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049278.1 Alternate UMICH_Zoey_3.1

Range

52888242..52891882 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038501427.1 → XP_038357355.1 peroxiredoxin-5, mitochondrial isoform X1
XM_038501429.1 → XP_038357357.1 peroxiredoxin-5, mitochondrial isoform X3
XM_038501428.1 → XP_038357356.1 peroxiredoxin-5, mitochondrial isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049759.1 Alternate UNSW_CanFamBas_1.0

Range

52474829..52478470 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038628265.1 → XP_038484193.1 peroxiredoxin-5, mitochondrial isoform X1
XM_038628267.1 → XP_038484195.1 peroxiredoxin-5, mitochondrial isoform X3
XM_038628266.1 → XP_038484194.1 peroxiredoxin-5, mitochondrial isoform X2

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049239.1 Alternate UU_Cfam_GSD_1.0

Range

53258704..53262348 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038564112.1 → XP_038420040.1 peroxiredoxin-5, mitochondrial isoform X1

Conserved Domains (1) summary

cd03013
Location:20 → 174

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
XM_038564114.1 → XP_038420042.1 peroxiredoxin-5, mitochondrial isoform X3

Conserved Domains (1) summary

cd03013
Location:6 → 160

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
XM_038564113.1 → XP_038420041.1 peroxiredoxin-5, mitochondrial isoform X2

Conserved Domains (1) summary

cd03013
Location:16 → 170

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

51358049..51361693 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038453801.1 → XP_038309729.1 peroxiredoxin-5, mitochondrial isoform X1

Conserved Domains (1) summary

cd03013
Location:20 → 174

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
XM_533241.7 → XP_533241.5 peroxiredoxin-5, mitochondrial isoform X3

Conserved Domains (1) summary

cd03013
Location:6 → 160

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
XM_038453803.1 → XP_038309731.1 peroxiredoxin-5, mitochondrial isoform X2

Conserved Domains (1) summary

cd03013
Location:16 → 170

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...