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MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 480352, updated on 5-Mar-2024

Summary

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Official Symbol
MTHFD1provided by VGNC
Official Full Name
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1provided by VGNC
Primary source
VGNC:VGNC:43472
See related
Ensembl:ENSCAFG00845002014
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See MTHFD1 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
28
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (39053525..39110717)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (38523089..38581005)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (39107099..39164254)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (38674867..38732782)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (38746016..38804174)

Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097074 Neighboring gene coiled-coil domain-containing protein 170-like Neighboring gene nucleoside diphosphate kinase A-like Neighboring gene U4 spliceosomal RNA Neighboring gene A-kinase anchoring protein 5 Neighboring gene zinc finger and BTB domain containing 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables formate-tetrahydrofolate ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methenyltetrahydrofolate cyclohydrolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
C-1-tetrahydrofolate synthase, cytoplasmic
XP_038339387.1
XP_038339388.1
XP_038400847.1
XP_038400848.1
XP_038445110.1
XP_038464963.1
XP_038464964.1
XP_038529768.1
XP_038529769.1
XP_537476.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051812.1 Reference ROS_Cfam_1.0

    Range
    39053525..39110717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038673840.1 → XP_038529768.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A8C0P838, A0A8C0QQP0, A0A8I3MJJ7
    Related
    ENSCAFP00845002795.1, ENSCAFT00845003522.1
    Conserved Domains (2) summary
    PLN02759
    Location:310 → 935
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  2. XM_038673841.1 → XP_038529769.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

    UniProtKB/TrEMBL
    A0A8C0QKW9
    Conserved Domains (2) summary
    PLN02759
    Location:310 → 910
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049268.1 Alternate UMICH_Zoey_3.1

    Range
    38674867..38732782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038483459.1 → XP_038339387.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

    Conserved Domains (2) summary
    PLN02759
    Location:310 → 935
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  2. XM_038483460.1 → XP_038339388.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

    Conserved Domains (2) summary
    PLN02759
    Location:310 → 910
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

    Range
    38746016..38804174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038609035.1 → XP_038464963.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

    Conserved Domains (2) summary
    PLN02759
    Location:310 → 935
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  2. XM_038609036.1 → XP_038464964.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

    Conserved Domains (2) summary
    PLN02759
    Location:310 → 910
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

    Range
    39107099..39164254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038544919.1 → XP_038400847.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A8C0P838, A0A8C0QQP0, A0A8I3MJJ7
    Conserved Domains (2) summary
    PLN02759
    Location:310 → 935
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  2. XM_038544920.1 → XP_038400848.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

    UniProtKB/TrEMBL
    A0A8C0QKW9
    Conserved Domains (2) summary
    PLN02759
    Location:310 → 910
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    38523089..38581005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_537476.7 → XP_537476.2  C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A8C0P838, A0A8C0QQP0, A0A8I3MJJ7
    Conserved Domains (2) summary
    PLN02759
    Location:310 → 935
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  2. XM_038589182.1 → XP_038445110.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

    UniProtKB/TrEMBL
    A0A8C0QKW9
    Conserved Domains (2) summary
    PLN02759
    Location:310 → 910
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
Nucleotide Protein
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