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OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF [ Canis lupus familiaris (dog) ]

Gene ID: 482206, updated on 5-Mar-2024

Summary

Official Symbol
OBSCNprovided by VGNC
Official Full Name
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEFprovided by VGNC
Primary source
VGNC:VGNC:49693
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
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Genomic context

See OBSCN in Genome Data Viewer
Location:
chromosome: 14
Exon count:
106
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 14 NC_051818.1 (380493..503404, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 14 NC_006596.4 (368668..495174)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 14 NC_049235.1 (337710..460914, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 14 NC_049274.1 (566842..694225, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 14 NC_049755.1 (327479..475088, complement)

Chromosome 14 - NC_051818.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106559712 Neighboring gene tripartite motif containing 17 Neighboring gene tripartite motif containing 11 Neighboring gene iron-sulfur cluster assembly factor IBA57 Neighboring gene gap junction protein gamma 2

Genomic regions, transcripts, and products

General protein information

Preferred Names
obscurin; LOW QUALITY PROTEIN: obscurin
XP_038293789.1
XP_038293790.1
XP_038293791.1
XP_038293793.1
XP_038293798.1
XP_038293806.1
XP_038293808.1
XP_038293813.1
XP_038293816.1
XP_038293824.1
XP_038350051.1
XP_038350052.1
XP_038350053.1
XP_038350054.1
XP_038350055.1
XP_038350056.1
XP_038350057.1
XP_038350058.1
XP_038350059.1
XP_038412346.1
XP_038412347.1
XP_038412348.1
XP_038412349.1
XP_038412350.1
XP_038412351.1
XP_038412352.1
XP_038412353.1
XP_038412354.1
XP_038412356.1
XP_038476289.1
XP_038541974.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051818.1 Reference ROS_Cfam_1.0

    Range
    380493..503404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038686046.1XP_038541974.1  LOW QUALITY PROTEIN: obscurin isoform X1

    Conserved Domains (12) summary
    cd12025
    Location:56945756
    SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
    smart00060
    Location:76237701
    FN3; Fibronectin type 3 domain
    smart00409
    Location:37703847
    IG; Immunoglobulin
    smart00410
    Location:40424118
    IG_like; Immunoglobulin like
    cd00063
    Location:45764661
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13239
    Location:59746098
    PH_Obscurin; Obscurin pleckstrin homology (PH) domain
    pfam07679
    Location:998
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:891893
    Ig; Ig strand A [structural motif]
    cd20971
    Location:61066196
    IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
    cl02571
    Location:57895965
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl11960
    Location:891972
    Ig; Immunoglobulin domain
    cl21453
    Location:65586814
    PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049274.1 Alternate UMICH_Zoey_3.1

    Range
    566842..694225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038494126.1XP_038350054.1  obscurin isoform X4

  2. XM_038494125.1XP_038350053.1  obscurin isoform X3

  3. XM_038494124.1XP_038350052.1  obscurin isoform X2

  4. XM_038494123.1XP_038350051.1  obscurin isoform X1

  5. XM_038494127.1XP_038350055.1  obscurin isoform X5

  6. XM_038494128.1XP_038350056.1  obscurin isoform X6

  7. XM_038494129.1XP_038350057.1  obscurin isoform X7

  8. XM_038494131.1XP_038350059.1  obscurin isoform X9

  9. XM_038494130.1XP_038350058.1  obscurin isoform X8

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049755.1 Alternate UNSW_CanFamBas_1.0

    Range
    327479..475088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038620361.1XP_038476289.1  LOW QUALITY PROTEIN: obscurin isoform X10

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049235.1 Alternate UU_Cfam_GSD_1.0

    Range
    337710..460914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038556423.1XP_038412351.1  obscurin isoform X16

  2. XM_038556421.1XP_038412349.1  obscurin isoform X14

  3. XM_038556420.1XP_038412348.1  obscurin isoform X13

  4. XM_038556419.1XP_038412347.1  obscurin isoform X12

  5. XM_038556418.1XP_038412346.1  obscurin isoform X11

  6. XM_038556422.1XP_038412350.1  obscurin isoform X15

  7. XM_038556424.1XP_038412352.1  obscurin isoform X17

  8. XM_038556425.1XP_038412353.1  obscurin isoform X18

  9. XM_038556428.1XP_038412356.1  obscurin isoform X20

  10. XM_038556426.1XP_038412354.1  obscurin isoform X19

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006596.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    368668..495174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038437861.1XP_038293789.1  obscurin isoform X21

    Conserved Domains (12) summary
    cd12025
    Location:57905852
    SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
    smart00060
    Location:77197797
    FN3; Fibronectin type 3 domain
    smart00409
    Location:38663943
    IG; Immunoglobulin
    smart00410
    Location:41384214
    IG_like; Immunoglobulin like
    cd00063
    Location:46724757
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13239
    Location:60706194
    PH_Obscurin; Obscurin pleckstrin homology (PH) domain
    pfam07679
    Location:998
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:891893
    Ig; Ig strand A [structural motif]
    cd20971
    Location:62026292
    IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
    cl02571
    Location:58856061
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl11960
    Location:891972
    Ig; Immunoglobulin domain
    cl21453
    Location:66546910
    PKc_like; Protein Kinases, catalytic domain
  2. XM_038437862.1XP_038293790.1  obscurin isoform X22

    Conserved Domains (12) summary
    cd12025
    Location:57905852
    SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
    smart00060
    Location:76567734
    FN3; Fibronectin type 3 domain
    smart00409
    Location:39574032
    IG; Immunoglobulin
    smart00410
    Location:38663943
    IG_like; Immunoglobulin like
    cd00063
    Location:46724757
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13239
    Location:60706194
    PH_Obscurin; Obscurin pleckstrin homology (PH) domain
    pfam07679
    Location:998
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:891893
    Ig; Ig strand A [structural motif]
    cd20971
    Location:62026292
    IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
    cl02571
    Location:58856061
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl11960
    Location:891972
    Ig; Immunoglobulin domain
    cl21453
    Location:65916847
    PKc_like; Protein Kinases, catalytic domain
  3. XM_038437878.1XP_038293806.1  obscurin isoform X26

    Conserved Domains (12) summary
    cd12025
    Location:56105672
    SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
    smart00060
    Location:75397617
    FN3; Fibronectin type 3 domain
    smart00409
    Location:41384214
    IG; Immunoglobulin
    smart00410
    Location:38663943
    IG_like; Immunoglobulin like
    cd00063
    Location:44924577
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13239
    Location:58906014
    PH_Obscurin; Obscurin pleckstrin homology (PH) domain
    pfam07679
    Location:998
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:891893
    Ig; Ig strand A [structural motif]
    cd20971
    Location:60226112
    IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
    cl02571
    Location:57055881
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl11960
    Location:891972
    Ig; Immunoglobulin domain
    cl21453
    Location:64746730
    PKc_like; Protein Kinases, catalytic domain
  4. XM_038437865.1XP_038293793.1  obscurin isoform X24

    Conserved Domains (12) summary
    cd12025
    Location:56145676
    SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
    smart00060
    Location:75437621
    FN3; Fibronectin type 3 domain
    smart00409
    Location:36903767
    IG; Immunoglobulin
    smart00410
    Location:39624038
    IG_like; Immunoglobulin like
    cd00063
    Location:44964581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13239
    Location:58946018
    PH_Obscurin; Obscurin pleckstrin homology (PH) domain
    pfam07679
    Location:998
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:891893
    Ig; Ig strand A [structural motif]
    cd20971
    Location:60266116
    IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
    cl02571
    Location:57095885
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl11960
    Location:891972
    Ig; Immunoglobulin domain
    cl21453
    Location:64786734
    PKc_like; Protein Kinases, catalytic domain
  5. XM_038437863.1XP_038293791.1  obscurin isoform X23

    Conserved Domains (12) summary
    cd12025
    Location:57025764
    SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
    smart00060
    Location:76317709
    FN3; Fibronectin type 3 domain
    smart00409
    Location:37783855
    IG; Immunoglobulin
    smart00410
    Location:40504126
    IG_like; Immunoglobulin like
    cd00063
    Location:45844669
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13239
    Location:59826106
    PH_Obscurin; Obscurin pleckstrin homology (PH) domain
    pfam07679
    Location:998
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:891893
    Ig; Ig strand A [structural motif]
    cd20971
    Location:61146204
    IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
    cl02571
    Location:57975973
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl11960
    Location:891972
    Ig; Immunoglobulin domain
    cl21453
    Location:65666822
    PKc_like; Protein Kinases, catalytic domain
  6. XM_038437870.1XP_038293798.1  obscurin isoform X25

    Conserved Domains (12) summary
    cd12025
    Location:56145676
    SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
    smart00060
    Location:75437621
    FN3; Fibronectin type 3 domain
    smart00409
    Location:39624038
    IG; Immunoglobulin
    smart00410
    Location:36903767
    IG_like; Immunoglobulin like
    cd00063
    Location:44964581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13239
    Location:58946018
    PH_Obscurin; Obscurin pleckstrin homology (PH) domain
    pfam07679
    Location:998
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:891893
    Ig; Ig strand A [structural motif]
    cd20971
    Location:60266116
    IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
    cl02571
    Location:57095885
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl11960
    Location:891972
    Ig; Immunoglobulin domain
    cl21453
    Location:64786734
    PKc_like; Protein Kinases, catalytic domain
  7. XM_038437880.1XP_038293808.1  obscurin isoform X27

    Conserved Domains (11) summary
    cd12025
    Location:57905852
    SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
    smart00409
    Location:38663943
    IG; Immunoglobulin
    smart00410
    Location:30693145
    IG_like; Immunoglobulin like
    cd00063
    Location:46724757
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13239
    Location:60706194
    PH_Obscurin; Obscurin pleckstrin homology (PH) domain
    pfam07679
    Location:998
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:891893
    Ig; Ig strand A [structural motif]
    cd20971
    Location:62026292
    IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
    cl02571
    Location:58856061
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl11960
    Location:891972
    Ig; Immunoglobulin domain
    cl21453
    Location:66546844
    PKc_like; Protein Kinases, catalytic domain
  8. XM_038437885.1XP_038293813.1  obscurin isoform X28

    Conserved Domains (12) summary
    PHA03201
    Location:64326502
    PHA03201; uracil DNA glycosylase; Provisional
    smart00015
    Location:50535074
    IQ; Calmodulin-binding motif
    cd12025
    Location:57905852
    SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
    smart00409
    Location:44084481
    IG; Immunoglobulin
    smart00410
    Location:38663943
    IG_like; Immunoglobulin like
    cd00063
    Location:46724757
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13239
    Location:60706194
    PH_Obscurin; Obscurin pleckstrin homology (PH) domain
    pfam07679
    Location:998
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:891893
    Ig; Ig strand A [structural motif]
    cd20971
    Location:62026292
    IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
    cl02571
    Location:58856061
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl11960
    Location:891972
    Ig; Immunoglobulin domain
  9. XM_038437896.1XP_038293824.1  obscurin isoform X30

    Conserved Domains (12) summary
    PHA03201
    Location:62526322
    PHA03201; uracil DNA glycosylase; Provisional
    smart00015
    Location:48734894
    IQ; Calmodulin-binding motif
    cd12025
    Location:56105672
    SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
    smart00409
    Location:30693145
    IG; Immunoglobulin
    smart00410
    Location:38663943
    IG_like; Immunoglobulin like
    cd00063
    Location:44924577
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13239
    Location:58906014
    PH_Obscurin; Obscurin pleckstrin homology (PH) domain
    pfam07679
    Location:998
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:891893
    Ig; Ig strand A [structural motif]
    cd20971
    Location:60226112
    IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
    cl02571
    Location:57055881
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl11960
    Location:891972
    Ig; Immunoglobulin domain
  10. XM_038437888.1XP_038293816.1  obscurin isoform X29

    Conserved Domains (11) summary
    smart00015
    Location:50535074
    IQ; Calmodulin-binding motif
    cd12025
    Location:57905852
    SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
    smart00409
    Location:38663943
    IG; Immunoglobulin
    smart00410
    Location:39574032
    IG_like; Immunoglobulin like
    cd00063
    Location:46724757
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13239
    Location:60706194
    PH_Obscurin; Obscurin pleckstrin homology (PH) domain
    pfam07679
    Location:998
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:891893
    Ig; Ig strand A [structural motif]
    cd20971
    Location:62026292
    IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
    cl02571
    Location:58856061
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl11960
    Location:891972
    Ig; Immunoglobulin domain