GRM5 glutamate metabotropic receptor 5 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: GRM5provided by VGNC
Official Full Name: glutamate metabotropic receptor 5provided by VGNC
Primary source: VGNC:VGNC:41512
See related: Ensembl:ENSCAFG00845025940
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	21	NC_051825.1 (11158622..11676400)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	21	NC_006603.4 (10835710..11353650)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	21	NC_049242.1 (11072936..11589092)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	21	NC_049281.1 (10948659..11467273)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	21	NC_049762.1 (11025934..11536817)

Chromosome 21 - NC_051825.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info	PubMed
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info	PubMed
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: metabotropic glutamate receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051825.1 Reference ROS_Cfam_1.0

Range

11158622..11676400

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038429812.1 → XP_038285740.1 metabotropic glutamate receptor 5 isoform X1

UniProtKB/TrEMBL

A0A8C0N5F2, A0A8I3PW94

Related

ENSCAFP00845035917.1, ENSCAFT00845045763.1

Conserved Domains (4) summary

cd15450
Location:578 → 827

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 497

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:508 → 558

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1189 → 1238

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_038429811.1 → XP_038285739.1 metabotropic glutamate receptor 5 isoform X1

UniProtKB/TrEMBL

A0A8C0N5F2, A0A8I3PW94

Conserved Domains (4) summary

cd15450
Location:578 → 827

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 497

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:508 → 558

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1189 → 1238

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_038429814.1 → XP_038285742.1 metabotropic glutamate receptor 5 isoform X2

UniProtKB/TrEMBL

A0A8C0RIG1, A0A8I3PRY2

Related

ENSCAFP00845036013.1, ENSCAFT00845045870.1

Conserved Domains (4) summary

cd15450
Location:578 → 827

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 497

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:508 → 558

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1157 → 1206

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

Alternate UMICH_Zoey_3.1

Genomic

NC_049281.1 Alternate UMICH_Zoey_3.1

Range

10948659..11467273

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038505211.1 → XP_038361139.1 metabotropic glutamate receptor 5 isoform X1
XM_038505210.1 → XP_038361138.1 metabotropic glutamate receptor 5 isoform X1
XM_038505212.1 → XP_038361140.1 metabotropic glutamate receptor 5 isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049762.1 Alternate UNSW_CanFamBas_1.0

Range

11025934..11536817

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038632495.1 → XP_038488423.1 metabotropic glutamate receptor 5 isoform X1
XM_038632494.1 → XP_038488422.1 metabotropic glutamate receptor 5 isoform X1
XM_038632496.1 → XP_038488424.1 metabotropic glutamate receptor 5 isoform X2

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049242.1 Alternate UU_Cfam_GSD_1.0

Range

11072936..11589092

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038568353.1 → XP_038424281.1 metabotropic glutamate receptor 5 isoform X3

UniProtKB/TrEMBL

A0A8C0TBH6

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

10835710..11353650

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005633379.3 → XP_005633436.2 metabotropic glutamate receptor 5 isoform X1

UniProtKB/TrEMBL

A0A8C0N5F2, A0A8P0SR50

Conserved Domains (4) summary

cd15450
Location:578 → 827

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 497

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:508 → 558

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1187 → 1236

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_843590.6 → XP_848683.2 metabotropic glutamate receptor 5 isoform X1

UniProtKB/TrEMBL

A0A8C0N5F2, A0A8P0SR50

Conserved Domains (4) summary

cd15450
Location:578 → 827

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 497

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:508 → 558

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1187 → 1236

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_851625.6 → XP_856718.2 metabotropic glutamate receptor 5 isoform X2

UniProtKB/TrEMBL

A0A8C0RIG1, A0A8P0S9Y8

Conserved Domains (4) summary

cd15450
Location:578 → 827

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 497

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:508 → 558

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1155 → 1204

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor