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NCAPG2 non-SMC condensin II complex subunit G2 [ Homo sapiens (human) ]

Gene ID: 54892, updated on 3-Apr-2024

Summary

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Official Symbol
NCAPG2provided by HGNC
Official Full Name
non-SMC condensin II complex subunit G2provided by HGNC
Primary source
HGNC:HGNC:21904
See related
Ensembl:ENSG00000146918 MIM:608532; AllianceGenome:HGNC:21904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
3KS; MTB; CAPG2; LUZP5; CAP-G2; hCAP-G2
Summary
This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Broad expression in testis (RPKM 7.7), bone marrow (RPKM 6.8) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
7q36.3
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (158631169..158704804, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (159858401..159932192, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (158423861..158497495, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158389617-158390116 Neighboring gene long intergenic non-protein coding RNA 1022 Neighboring gene microRNA 5707 Neighboring gene THAP domain containing 5 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158455355-158455856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158455857-158456356 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:158456637-158457836 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158496256-158496834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18867 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18868 Neighboring gene ribosomal protein L21 pseudogene 76 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:158526538-158527737 Neighboring gene extended synaptotagmin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158589571-158590070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158593246-158593746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158593747-158594247 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158596845-158597436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158604138-158604712 Neighboring gene Sharpr-MPRA regulatory region 8416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26932 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18869 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18873

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NCAPG2 contributes to the progression of malignant melanoma through regulating proliferation and metastasis. Feng Z, et al. Biochem Cell Biol, 2022 Dec 1. PMID 36265182
  2. NCAPG2 overexpression promotes hepatocellular carcinoma proliferation and metastasis through activating the STAT3 and NF-κB/miR-188-3p pathways. Meng F, et al. EBioMedicine, 2019 Jun. PMID 31176678, Free PMC Article
  3. NCAPG2 promotes tumour proliferation by regulating G2/M phase and associates with poor prognosis in lung adenocarcinoma. Zhan P, et al. J Cell Mol Med, 2017 Apr. PMID 27862966, Free PMC Article
  4. Circular RNA circ0001955 promotes cervical cancer tumorigenesis and metastasis via the miR-188-3p/NCAPG2 axis. Wang W, et al. J Transl Med, 2023 May 29. PMID 37248471, Free PMC Article
  5. microRNA-375 inhibits the malignant behaviors of hepatic carcinoma cells by targeting NCAPG2. Dai HT, et al. Neoplasma, 2022 Jan. PMID 34818025

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NCAPG2 promotes prostate cancer malignancy and stemness via STAT3/c-MYC signaling.
    Title: NCAPG2 promotes prostate cancer malignancy and stemness via STAT3/c-MYC signaling.
  2. The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2.
    Title: The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2.
  3. Circular RNA circ0001955 promotes cervical cancer tumorigenesis and metastasis via the miR-188-3p/NCAPG2 axis.
    Title: Circular RNA circ0001955 promotes cervical cancer tumorigenesis and metastasis via the miR-188-3p/NCAPG2 axis.
  4. NCAPG2 contributes to the progression of malignant melanoma through regulating proliferation and metastasis.
    Title: NCAPG2 contributes to the progression of malignant melanoma through regulating proliferation and metastasis.
  5. microRNA-375 inhibits the malignant behaviors of hepatic carcinoma cells by targeting NCAPG2.
    Title: microRNA-375 inhibits the malignant behaviors of hepatic carcinoma cells by targeting NCAPG2.
  6. NCAPG2 facilitates glioblastoma cells' malignancy and xenograft tumor growth via HBO1 activation by phosphorylation.
    Title: NCAPG2 facilitates glioblastoma cells' malignancy and xenograft tumor growth via HBO1 activation by phosphorylation.
  7. that NCAPG2 is an important oncogene that contributes to HCC proliferation and metastasis. NCAPG2 can activate both the STAT3 and NF-kappaB pathways and activated STAT3 positively regulates NCAPG2 expression.
    Title: NCAPG2 overexpression promotes hepatocellular carcinoma proliferation and metastasis through activating the STAT3 and NF-κB/miR-188-3p pathways.
  8. data suggest that impaired function of NCAPG2 results in a severe condensinopathy, and they highlight the potential utility of examining candidate pathogenic lesions beyond the primary disease locus
    Title: Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies.
  9. increased NCAPG2 expression could regulate cell proliferation and identified as a poor prognostic biomarker in lung adenocarcinoma.
    Title: NCAPG2 promotes tumour proliferation by regulating G2/M phase and associates with poor prognosis in lung adenocarcinoma.
  10. Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair
    Title: Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Khan-Khan-Katsanis syndrome
MedGen: C5193110 OMIM: 618460 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ20311

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables bHLH transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome condensation IEA
Inferred from Electronic Annotation
more info
  
involved_in erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in inner cell mass cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of chromosome condensation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome separation ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of condensin complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane HDA PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
condensin-2 complex subunit G2
Names
chromosome-associated protein G2
leucine zipper protein 5
more than blood homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047159.1 RefSeqGene

    Range
    5028..78663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001281932.2 → NP_001268861.1  condensin-2 complex subunit G2 isoform a

    See identical proteins and their annotated locations for NP_001268861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AC019084, AC093662, AK092008, DB069860, DW419642
    Consensus CDS
    CCDS43686.1
    UniProtKB/Swiss-Prot
    A4D228, Q7Z3J9, Q86XI2, Q8WUG8, Q9BRX6, Q9H8S2, Q9H9K6
    UniProtKB/TrEMBL
    B3KRQ2
    Related
    ENSP00000386569.1, ENST00000409423.5
    Conserved Domains (2) summary
    pfam12422
    Location:213 → 361
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    sd00044
    Location:368 → 405
    HEAT; HEAT repeat [structural motif]

  2. NM_001281933.2 → NP_001268862.1  condensin-2 complex subunit G2 isoform b

    See identical proteins and their annotated locations for NP_001268862.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon which results in a frameshift. The encoded isoform (b) has a distinct C-terminus and is longer than isoform a.
    Source sequence(s)
    AC019084, BX537845, DB069860
    Consensus CDS
    CCDS64816.1
    UniProtKB/TrEMBL
    B3KRQ2
    Related
    ENSP00000387007.3, ENST00000409339.3
    Conserved Domains (3) summary
    COG5096
    Location:339 → 484
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    sd00044
    Location:368 → 405
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:213 → 361
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  3. NM_017760.7 → NP_060230.5  condensin-2 complex subunit G2 isoform a

    See identical proteins and their annotated locations for NP_060230.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093662, BC043404, DB069860, DW419642
    Consensus CDS
    CCDS43686.1
    UniProtKB/Swiss-Prot
    A4D228, Q7Z3J9, Q86XI2, Q8WUG8, Q9BRX6, Q9H8S2, Q9H9K6
    UniProtKB/TrEMBL
    B3KRQ2
    Related
    ENSP00000348657.3, ENST00000356309.8
    Conserved Domains (2) summary
    pfam12422
    Location:213 → 361
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    sd00044
    Location:368 → 405
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_104054.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains three alternate exons and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC093662, BC028618, DB069860, DW419642
    Related
    ENST00000432615.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    158631169..158704804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420547.1 → XP_047276503.1  condensin-2 complex subunit G2 isoform X7

  2. XM_017012376.3 → XP_016867865.1  condensin-2 complex subunit G2 isoform X6

    UniProtKB/TrEMBL
    B3KRQ2

  3. XM_005249547.4 → XP_005249604.1  condensin-2 complex subunit G2 isoform X5

    See identical proteins and their annotated locations for XP_005249604.1

    UniProtKB/TrEMBL
    B3KRQ2
    Related
    ENSP00000408080.1, ENST00000441982.5
    Conserved Domains (2) summary
    pfam12422
    Location:213 → 361
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    sd00044
    Location:368 → 405
    HEAT; HEAT repeat [structural motif]

  4. XM_047420548.1 → XP_047276504.1  condensin-2 complex subunit G2 isoform X7

  5. XM_047420546.1 → XP_047276502.1  condensin-2 complex subunit G2 isoform X6

  6. XM_047420544.1 → XP_047276500.1  condensin-2 complex subunit G2 isoform X5

  7. XM_047420545.1 → XP_047276501.1  condensin-2 complex subunit G2 isoform X5

  8. XM_047420539.1 → XP_047276495.1  condensin-2 complex subunit G2 isoform X2

    UniProtKB/Swiss-Prot
    A4D228, Q7Z3J9, Q86XI2, Q8WUG8, Q9BRX6, Q9H8S2, Q9H9K6

  9. XM_011516362.2 → XP_011514664.1  condensin-2 complex subunit G2 isoform X9

    UniProtKB/TrEMBL
    B4DXB7

  10. XM_047420542.1 → XP_047276498.1  condensin-2 complex subunit G2 isoform X4

  11. XM_047420540.1 → XP_047276496.1  condensin-2 complex subunit G2 isoform X3

  12. XM_047420543.1 → XP_047276499.1  condensin-2 complex subunit G2 isoform X4

  13. XM_047420541.1 → XP_047276497.1  condensin-2 complex subunit G2 isoform X3

  14. XM_011516357.3 → XP_011514659.1  condensin-2 complex subunit G2 isoform X1

    See identical proteins and their annotated locations for XP_011514659.1

    UniProtKB/TrEMBL
    B3KRQ2
    Related
    ENST00000467785.5
    Conserved Domains (3) summary
    COG5096
    Location:339 → 484
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    sd00044
    Location:368 → 405
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:213 → 361
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  15. XM_047420538.1 → XP_047276494.1  condensin-2 complex subunit G2 isoform X1

  16. XM_011516358.4 → XP_011514660.1  condensin-2 complex subunit G2 isoform X8

    UniProtKB/TrEMBL
    B3KRQ2
    Conserved Domains (2) summary
    pfam12422
    Location:213 → 361
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    sd00044
    Location:368 → 405
    HEAT; HEAT repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    159858401..159932192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358530.1 → XP_054214505.1  condensin-2 complex subunit G2 isoform X7

  2. XM_054358528.1 → XP_054214503.1  condensin-2 complex subunit G2 isoform X6

  3. XM_054358525.1 → XP_054214500.1  condensin-2 complex subunit G2 isoform X5

  4. XM_054358531.1 → XP_054214506.1  condensin-2 complex subunit G2 isoform X7

  5. XM_054358529.1 → XP_054214504.1  condensin-2 complex subunit G2 isoform X6

  6. XM_054358526.1 → XP_054214501.1  condensin-2 complex subunit G2 isoform X5

  7. XM_054358527.1 → XP_054214502.1  condensin-2 complex subunit G2 isoform X5

  8. XM_054358520.1 → XP_054214495.1  condensin-2 complex subunit G2 isoform X2

    UniProtKB/Swiss-Prot
    A4D228, Q7Z3J9, Q86XI2, Q8WUG8, Q9BRX6, Q9H8S2, Q9H9K6

  9. XM_054358533.1 → XP_054214508.1  condensin-2 complex subunit G2 isoform X9

  10. XM_054358523.1 → XP_054214498.1  condensin-2 complex subunit G2 isoform X4

  11. XM_054358521.1 → XP_054214496.1  condensin-2 complex subunit G2 isoform X3

  12. XM_054358524.1 → XP_054214499.1  condensin-2 complex subunit G2 isoform X4

  13. XM_054358522.1 → XP_054214497.1  condensin-2 complex subunit G2 isoform X3

  14. XM_054358518.1 → XP_054214493.1  condensin-2 complex subunit G2 isoform X1

  15. XM_054358519.1 → XP_054214494.1  condensin-2 complex subunit G2 isoform X1

  16. XM_054358532.1 → XP_054214507.1  condensin-2 complex subunit G2 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86XI2.1 GenPept UniProtKB/Swiss-Prot:Q86XI2

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