ppp2r2bb protein phosphatase 2, regulatory subunit B, beta b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppp2r2bbprovided by ZNC
Official Full Name: protein phosphatase 2, regulatory subunit B, beta bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-39
See related: Ensembl:ENSDARG00000099221 AllianceGenome:ZFIN:ZDB-GENE-041010-39
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ppp2r2b; zgc:101861
Summary: Predicted to enable protein phosphatase regulator activity. Predicted to be involved in peptidyl-serine dephosphorylation. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (41649341..41781240)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (41636126..41768030)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase regulator activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform; protein phosphatase 2, regulatory subunit B, beta b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030122.3 → NP_001025293.2 protein phosphatase 2, regulatory subunit B, beta b

Status: VALIDATED

Source sequence(s)

BX005397, CU929230

UniProtKB/TrEMBL

A0A0R4IEA6, A0A8M1N7E1

Related

ENSDARP00000131058.1, ENSDART00000169511.2

Conserved Domains (3) summary

COG5170
Location:17 → 438

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:27 → 75

7WD40; WD40 repeat [structural motif]

cl02567
Location:15 → 366

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

41649341..41781240

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017352797.2 → XP_017208286.1 protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform isoform X1

UniProtKB/TrEMBL

A0A2R8Q610, A0A8M6Z3N4

Related

ENSDARP00000149529.1, ENSDART00000181539.1
XM_021468863.1 → XP_021324538.1 protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform isoform X2

UniProtKB/TrEMBL

A0A8M9PCQ6

Related

ENSDARP00000152523.1, ENSDART00000192669.1

Conserved Domains (2) summary

COG5170
Location:14 → 428

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:17 → 65

7WD40; WD40 repeat [structural motif]