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mtpap mitochondrial poly(A) polymerase [ Danio rerio (zebrafish) ]

Gene ID: 563801, updated on 25-Apr-2024

Summary

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Official Symbol
mtpapprovided by ZNC
Official Full Name
mitochondrial poly(A) polymeraseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-101208-3
See related
Ensembl:ENSDARG00000076155 AllianceGenome:ZFIN:ZDB-GENE-101208-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable RNA adenylyltransferase activity. Predicted to be involved in mRNA polyadenylation. Predicted to be active in mitochondrion. Is expressed in head; ovary; and testis. Human ortholog(s) of this gene implicated in spastic ataxia 4. Orthologous to human MTPAP (mitochondrial poly(A) polymerase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See mtpap in Genome Data Viewer
Location:
chromosome: 12
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (23664279..23676265)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (23543031..23555044)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108191717 Neighboring gene mitogen-activated protein kinase kinase kinase 8 Neighboring gene junctional cadherin 5 associated a Neighboring gene supervillin a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Terminal Uridylyltransferases Execute Programmed Clearance of Maternal Transcriptome in Vertebrate Embryos. Chang H, et al. Mol Cell, 2018 Apr 5. PMID 29625039
  2. Hen1 is required for oocyte development and piRNA stability in zebrafish. Kamminga LM, et al. EMBO J, 2010 Nov 3. PMID 20859253, Free PMC Article
  3. Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency. Zhang Q, et al. Nucleic Acids Res, 2021 May 7. PMID 33836087, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
poly(A) RNA polymerase, mitochondrial
Names
TUTase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    23664279..23676265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480322.1 → XP_021335997.1  poly(A) RNA polymerase, mitochondrial

    UniProtKB/TrEMBL
    A0A8M9PX24, E7FEW2
    Related
    ENSDARP00000100165.2, ENSDART00000111334.4
    Conserved Domains (3) summary
    cd05402
    Location:222 → 359
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    cl17169
    Location:89 → 139
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl27230
    Location:206 → 511
    PAP_assoc; Cid1 family poly A polymerase

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394842.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    31660..43924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_687164.8 → XP_692256.5  poly(A) RNA polymerase, mitochondrial

    UniProtKB/TrEMBL
    A0A8M9PX24, E7FEW2
    Conserved Domains (3) summary
    cd05402
    Location:222 → 359
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    cl17169
    Location:89 → 139
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl27230
    Location:206 → 511
    PAP_assoc; Cid1 family poly A polymerase
Nucleotide Protein Strain
Heading Accession and Version

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