carmil2 capping protein regulator and myosin 1 linker 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: carmil2provided by ZNC
Official Full Name: capping protein regulator and myosin 1 linker 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050419-197
See related: Ensembl:ENSDARG00000056639 AllianceGenome:ZFIN:ZDB-GENE-050419-197
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rltpr; wu:fk64c08; si:dkey-6e12.3; si:dkey-6e12.4
Summary: Predicted to act upstream of or within cell migration and maintenance of cell polarity. Predicted to be located in cytoplasm and plasma membrane. Is expressed in central nervous system; eye; and pronephric duct. Human ortholog(s) of this gene implicated in immunodeficiency 58. Orthologous to human CARMIL2 (capping protein regulator and myosin 1 linker 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (22302635..22396371)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (22313569..22407305)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: capping protein, Arp2/3 and myosin-I linker protein 2; F-actin-uncapping protein RLTPR

Names: RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001317766.1 → NP_001304695.1 capping protein, Arp2/3 and myosin-I linker protein 2

Status: PROVISIONAL

Source sequence(s)

KR912199

UniProtKB/TrEMBL

A0A0P0CJS1, F6NI44

Related

ENSDARP00000123542.2, ENSDART00000141051.4

Conserved Domains (4) summary

cd00116
Location:397 → 648

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:232 → 267

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:367 → 393

LRR_AMN1; leucine-rich repeat [structural motif]

pfam16000
Location:783 → 1135

CARMIL_C; CARMIL C-terminus

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

22302635..22396371

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467685.1 → XP_021323360.1 F-actin-uncapping protein RLTPR isoform X1

UniProtKB/TrEMBL

A0A8M9PQB9

Conserved Domains (2) summary

pfam16000
Location:684 → 1006

CARMIL_C; CARMIL C-terminus

cl26161
Location:309 → 553

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...