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c7b complement component 7b [ Danio rerio (zebrafish) ]

Gene ID: 570832, updated on 27-Mar-2024

Summary

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Official Symbol
c7bprovided by ZNC
Official Full Name
complement component 7bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-021120-1
See related
Ensembl:ENSDARG00000057121 AllianceGenome:ZFIN:ZDB-GENE-021120-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
c7; cb349; wu:fa01f03; si:dkey-246j23.5
Summary
Predicted to act upstream of or within complement activation, classical pathway; cytolysis; and innate immune response. Predicted to be located in extracellular region. Predicted to be part of membrane attack complex. Is expressed in central nervous system and yolk syncytial layer. Human ortholog(s) of this gene implicated in complement component 7 deficiency. Orthologous to human C7 (complement C7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See c7b in Genome Data Viewer
Location:
chromosome: 21
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (20901280..20915291)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (20864654..20878711)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene complement component 6, duplicate 1 Neighboring gene succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial-like Neighboring gene complement component 6, duplicate 2 Neighboring gene regulator of G protein signaling 7 binding protein b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression of complement component C7 and involvement in innate immune responses to bacteria in grass carp. Shen Y, et al. Fish Shellfish Immunol, 2012 Aug. PMID 22617254
  2. Identification and functional analysis of the perforin-1 like gene in disease resistance in half smooth tongue sole (Cynoglossus semilaevis). Fu X, et al. Dev Comp Immunol, 2021 Sep. PMID 34004267
  3. Rapid, Dynamic Activation of Müller Glial Stem Cell Responses in Zebrafish. Sifuentes CJ, et al. Invest Ophthalmol Vis Sci, 2016 Oct 1. PMID 27699411, Free PMC Article
  4. Metabolism disruption analysis of zebrafish larvae in response to BPA and BPA analogs based on RNA-Seq technique. Qiu W, et al. Ecotoxicol Environ Saf, 2019 Jun 15. PMID 30826544
  5. Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis. Van Gennip JLM, et al. Sci Adv, 2018 Dec. PMID 30547092, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in complement activation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of membrane attack complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of membrane attack complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
complement component 7b; complement component C7
Names
C7-1
complement component 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386266.1 → NP_001373195.1  complement component 7b precursor

    Status: VALIDATED

    Source sequence(s)
    BX511186
    UniProtKB/TrEMBL
    A0A8M9PWA7, F1QF24, F1QKJ3
    Conserved Domains (6) summary
    PHA02639
    Location:563 → 689
    PHA02639; EEV host range protein; Provisional
    smart00209
    Location:40 → 90
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:96 → 128
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:227 → 443
    MACPF; MAC/Perforin domain
    pfam18434
    Location:783 → 831
    Kazal_3; Kazal-type serine protease inhibitor domain
    cl20168
    Location:697 → 757
    Kazal_3; Kazal-type serine protease inhibitor domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    20901280..20915291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161237.4 → XP_005161294.1  complement component C7

    UniProtKB/TrEMBL
    F1QF24
    Related
    ENSDARP00000114284.1, ENSDART00000132741.2
    Conserved Domains (6) summary
    PHA02639
    Location:563 → 689
    PHA02639; EEV host range protein; Provisional
    smart00209
    Location:40 → 90
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:96 → 128
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:227 → 443
    MACPF; MAC/Perforin domain
    pfam18434
    Location:783 → 831
    Kazal_3; Kazal-type serine protease inhibitor domain
    cl20168
    Location:697 → 757
    Kazal_3; Kazal-type serine protease inhibitor domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395089.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    76565..90576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473424.1 → XP_021329099.1  complement component C7

    Conserved Domains (6) summary
    PHA02639
    Location:563 → 689
    PHA02639; EEV host range protein; Provisional
    smart00209
    Location:40 → 90
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:96 → 128
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:227 → 443
    MACPF; MAC/Perforin domain
    pfam18434
    Location:783 → 831
    Kazal_3; Kazal-type serine protease inhibitor domain
    cl20168
    Location:697 → 757
    Kazal_3; Kazal-type serine protease inhibitor domain
Nucleotide Protein
Heading Accession and Version

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