U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

lrrc8c leucine rich repeat containing 8 VRAC subunit C [ Danio rerio (zebrafish) ]

Gene ID: 571216, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
lrrc8cprovided by ZNC
Official Full Name
leucine rich repeat containing 8 VRAC subunit Cprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2965
See related
Ensembl:ENSDARG00000099911 AllianceGenome:ZFIN:ZDB-GENE-030131-2965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc22f12; wu:fc22f12
Summary
Predicted to act upstream of or within ion transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Orthologous to human LRRC8C (leucine rich repeat containing 8 VRAC subunit C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See lrrc8c in Genome Data Viewer
Location:
chromosome: 6
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (25188023..25201810, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (25088214..25102001, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 326 Neighboring gene leucine rich repeat containing 8 VRAC subunit Db Neighboring gene kynurenine aminotransferase 3, tandem duplicate 1 Neighboring gene kynurenine aminotransferase 3, tandem duplicate 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Leucine-rich repeat containing 8A contributes to the expansion of brain ventricles in zebrafish embryos. Tseng YT, et al. Biol Open, 2020 Jan 29. PMID 31941702, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic anion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of monoatomic ion channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
volume-regulated anion channel subunit LRRC8C
Names
leucine rich repeat containing 8 family, member C

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326544.1 → NP_001313473.1  volume-regulated anion channel subunit LRRC8C

    Status: VALIDATED

    Source sequence(s)
    CR790380, CU928017
    UniProtKB/TrEMBL
    A0A8M1P936, E7F333
    Related
    ENSDARP00000137675.1, ENSDART00000168683.2
    Conserved Domains (4) summary
    cd00116
    Location:476 → 684
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:533 → 555
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 326
    Pannexin_like; Pannexin-like TM region of LRRC8
    pfam13855
    Location:626 → 684
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    25188023..25201810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools