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NKX2-8 NK2 homeobox 8 [ Canis lupus familiaris (dog) ]

Gene ID: 609776, updated on 5-Mar-2024

Summary

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Official Symbol
NKX2-8provided by VGNC
Official Full Name
NK2 homeobox 8provided by VGNC
Primary source
VGNC:VGNC:43835
See related
Ensembl:ENSCAFG00845002657
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See NKX2-8 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
2
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (15261532..15263403, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (14949217..14951088, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (15316460..15318331, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (14959436..14961305, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (15026476..15028341, complement)

Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119872840 Neighboring gene uncharacterized LOC111096999 Neighboring gene NK2 homeobox 1 Neighboring gene uncharacterized LOC119872844 Neighboring gene uncharacterized LOC119872843 Neighboring gene solute carrier family 25 member 21 Neighboring gene paired box 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans. Safra N, et al. PLoS Genet, 2013. PMID 23874236, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This is the first documentation of a potential role for NKX2-8 in the etiology of NTDs, made possible by investigating the molecular basis of naturally occurring mutations in dogs.
    Title: Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
homeobox protein Nkx-2.8
Names
NK2 transcription factor related, locus 8

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051812.1 Reference ROS_Cfam_1.0

    Range
    15261532..15263403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038672956.1 → XP_038528884.1  homeobox protein Nkx-2.8

    UniProtKB/TrEMBL
    A0A8C0TJ26, A0A8I3MFX0
    Related
    ENSCAFP00845003765.1, ENSCAFT00845004712.1
    Conserved Domains (1) summary
    pfam00046
    Location:87 → 141
    Homeobox; Homeobox domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049268.1 Alternate UMICH_Zoey_3.1

    Range
    14959436..14961305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038484461.1 → XP_038340389.1  homeobox protein Nkx-2.8

    Conserved Domains (1) summary
    pfam00046
    Location:87 → 141
    Homeobox; Homeobox domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

    Range
    15026476..15028341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038608157.1 → XP_038464085.1  homeobox protein Nkx-2.8

    Conserved Domains (1) summary
    pfam00046
    Location:87 → 141
    Homeobox; Homeobox domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

    Range
    15316460..15318331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038544032.1 → XP_038399960.1  homeobox protein Nkx-2.8

    UniProtKB/TrEMBL
    A0A8C0TJ26, A0A8I3MFX0
    Conserved Domains (1) summary
    pfam00046
    Location:87 → 141
    Homeobox; Homeobox domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    14949217..14951088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_847109.5 → XP_852202.2  homeobox protein Nkx-2.8

    UniProtKB/TrEMBL
    A0A8C0TJ26, A0A8I3MFX0
    Conserved Domains (1) summary
    pfam00046
    Location:87 → 141
    Homeobox; Homeobox domain
Nucleotide Protein
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