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MAMU-A major histocompatibility complex, class I, A [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 711832, updated on 9-Nov-2023

Summary

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Gene symbol
MAMU-A
Gene description
major histocompatibility complex, class I, A
See related
Ensembl:ENSMMUG00000056914
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
A1; MAMU-A1; MAMU-A2
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Genomic context

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Location:
chromosome: 4
Exon count:
8
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (139971826..139975522, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (30615883..30619384)

Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene putative uncharacterized protein ZNRD1-AS1 Neighboring gene uncharacterized LOC114677365 Neighboring gene uncharacterized LOC114669808 Neighboring gene patr class I histocompatibility antigen, A-2 alpha chain-like Neighboring gene uncharacterized LOC114677367 Neighboring gene 40S ribosomal protein SA-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeys. Osuna CE, et al. PLoS Pathog, 2014 Apr. PMID 24743648, Free PMC Article
  2. Identification of 17 novel major histocompatibility complex-A alleles in a population of Chinese-origin rhesus macaques. Ma X, et al. Tissue Antigens, 2009 Feb. PMID 19140828
  3. Allelic diversity within the high frequency Mamu-A2*05/Mane-A2*05 (Mane-A*06)/Mafa-A2*05 family of macaque MHC-A loci. Wu J, et al. Tissue Antigens, 2008 Jul. PMID 18498292, Free PMC Article
  4. Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeys. Kim EY, et al. J Virol, 2008 Jun. PMID 18367519, Free PMC Article
  5. First glimpse of the peptide presentation by rhesus macaque MHC class I: crystal structures of Mamu-A*01 complexed with two immunogenic SIV epitopes and insights into CTL escape. Chu F, et al. J Immunol, 2007 Jan 15. PMID 17202356

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest SIV (Simian immunodeficiency virus) peptides act as ligands for CD4+ T-Lymphocyte MAMU-A1 (MHC class I antigen) and for natural killer cell immunoglobulin-like receptor KIR3DL05; these interactions appear to assist SIV in immune evasion.
    Title: Suppression of a Natural Killer Cell Response by Simian Immunodeficiency Virus Peptides.
  2. TCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeys.
    Title: TCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeys.
  3. Higher KIR2DL4 copy numbers is associated with an increased IFN-gamma production in NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.
    Title: KIR2DL4 copy number variation is associated with CD4+ T-cell depletion and function of cytokine-producing NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.
  4. Two alleles expressed with high frequency in Chinese rhesus macaques, Mamu-A1*02601 and Mamu-B*08301 were characterized. These Mamu alleles share peptide-binding characteristics with the HLA-A2 and HLA-A3 supertypes, respectively.
    Title: Functional analysis of frequently expressed Chinese rhesus macaque MHC class I molecules Mamu-A1*02601 and Mamu-B*08301 reveals HLA-A2 and HLA-A3 supertypic specificities.
  5. Mamu-A*012 status was associated with significantly more frequent death (P = 0.04) as was TRIM5 alleles 6-11
    Title: Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys.
  6. Continued discovery of novel alleles within the Mamu-A2*05/ManeA2*05/MafaA2*05 family indicates that this major histocompatibility complex-A locus, though highly conserved across 3 species of macaques, has remained a dynamic entity during evolution.
    Title: Allelic diversity within the high frequency Mamu-A2*05/Mane-A2*05 (Mane-A*06)/Mafa-A2*05 family of macaque MHC-A loci.
  7. Escape mutations in Mamu-A*01 epitopes appeared first in Simian immunodeficiency virus Tat TL8 and then in SIV Gag p11C
    Title: Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeys.
  8. study are most relevant for the rational design of Mamu-A*01-restricted T-Lymphocytes, Cytotoxic epitopes with improved binding, as a step toward development of AIDS vaccines
    Title: First glimpse of the peptide presentation by rhesus macaque MHC class I: crystal structures of Mamu-A*01 complexed with two immunogenic SIV epitopes and insights into CTL escape.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables peptide antigen binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
major histocompatibility complex, class I, A
Names
MHC class 1 protein
MHC class I protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048246.2 → NP_001041711.2  major histocompatibility complex, class I, A precursor

    See identical proteins and their annotated locations for NP_001041711.2

    Status: VALIDATED

    Source sequence(s)
    AF157396, AJ551320
    UniProtKB/TrEMBL
    A0A0P1L555, A0A0P1L5H9, A0A7R9MWA7, D8VNI8, Q5TM75, Q9MXT0
    Conserved Domains (4) summary
    pfam00129
    Location:25 → 203
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    pfam06623
    Location:337 → 362
    MHC_I_C; MHC_I C-terminus
    cd00096
    Location:208 → 216
    Ig; Ig strand A [structural motif]
    cl11960
    Location:204 → 300
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041757.1 Reference Mmul_10 Primary Assembly

    Range
    139971826..139975522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028846910.1 → XP_028702743.1  major histocompatibility complex, class I, A isoform X2

    UniProtKB/TrEMBL
    A1JUR3, C5J9D2, D8VPN5, F7CPG3
    Related
    ENSMMUP00000034208.3, ENSMMUT00000041172.3
    Conserved Domains (3) summary
    pfam00129
    Location:25 → 203
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    pfam06623
    Location:337 → 362
    MHC_I_C; MHC_I C-terminus
    cd21026
    Location:204 → 300
    IgC1_MHC_Ia_HLA-B; Class Ia major histocompatibility complex (MHC) immunoglobulin domain of human leukocyte antigen (HLA) B and similar proteins; member of the C1-set of Ig superfamily (IgSF) domains

  2. XM_028846909.1 → XP_028702742.1  major histocompatibility complex, class I, A isoform X1

    UniProtKB/TrEMBL
    A1JUR3, D8VPN5
    Related
    ENSMMUP00000068447.1, ENSMMUT00000091212.1
    Conserved Domains (3) summary
    cd07698
    Location:207 → 299
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam06623
    Location:338 → 364
    MHC_I_C; MHC_I C-terminus
    pfam00129
    Location:26 → 203
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
Nucleotide Protein
Heading Accession and Version

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