U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

n Notch [ Ciona intestinalis (vase tunicate) ]

Gene ID: 723806, updated on 21-Dec-2023

Summary

Go to the top of the page Help
Gene symbol
n
Gene description
Notch
See related
Ensembl:ENSCING00000003521
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ciona intestinalis
Lineage
Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia; Cionidae; Ciona
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 9
Exon count:
52
Annotation release Status Assembly Chr Location
104 current KH (GCF_000224145.3) 9 NC_020174.2 (4753230..4786088)

Chromosome 9 - NC_020174.2Genomic Context describing neighboring genes Neighboring gene tenascin-R-like Neighboring gene nucleolar RNA helicase 2 Neighboring gene uncharacterized LOC108949782 Neighboring gene uncharacterized LOC104266051 Neighboring gene endoplasmic reticulum chaperone BiP-like Neighboring gene glucose 1-dehydrogenase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_020174.2 Chromosome 9 Reference KH Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Interaction of notochord-derived fibrinogen-like protein with Notch regulates the patterning of the central nervous system of Ciona intestinalis embryos. Yamada S, et al. Dev Biol, 2009 Apr 1. PMID 19171129
  2. A signalling relay involving Nodal and Delta ligands acts during secondary notochord induction in Ciona embryos. Hudson C, et al. Development, 2006 Aug. PMID 16835438
  3. Transcriptional regulation of the peripheral nervous system in Ciona intestinalis. Joyce Tang W, et al. Dev Biol, 2013 Jun 15. PMID 23545329
  4. Neural tube patterning by Ephrin, FGF and Notch signaling relays. Stolfi A, et al. Development, 2011 Dec. PMID 22110057
  5. Gene expression profiles of transcription factors and signaling molecules in the ascidian embryo: towards a comprehensive understanding of gene networks. Imai KS, et al. Development, 2004 Aug. PMID 15269171

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that the microRNA miR-124, which inhibits Notch signaling in epidermal sensory neurons (ESNs), is activated downstream of all the proneural factors, suggesting that these genes operate collectively in a regulatory network.
    Title: Transcriptional regulation of the peripheral nervous system in Ciona intestinalis.
  2. It was shown that the developing motor ganglion is patterned by sequential Ephrin/FGF8/MAPK and Delta/Notch signaling events. FGF8/MAPK attenuation by a localized Ephrin Ab signal specified posterior neuronal subtypes.
    Title: Neural tube patterning by Ephrin, FGF and Notch signaling relays.
  3. Laterally produced Nodal acts to specify the secondary notochord precursor.
    Title: A signalling relay involving Nodal and Delta ligands acts during secondary notochord induction in Ciona embryos.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Notch

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044360.1 → NP_001037825.1  Notch precursor

    See identical proteins and their annotated locations for NP_001037825.1

    Status: PROVISIONAL

    Source sequence(s)
    AB231293
    UniProtKB/TrEMBL
    A0A1W2VNY8, F7AZ47, Q2L697
    Related
    ENSCINP00000007252, ENSCINT00000007252
    Conserved Domains (10) summary
    COG0666
    Location:1857 → 1977
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:761 → 797
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00204
    Location:1950 → 2076
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00066
    Location:1449 → 1484
    Notch; LNR domain
    pfam06816
    Location:1529 → 1579
    NOD; NOTCH protein
    pfam07684
    Location:1626 → 1681
    NODP; NOTCH protein
    pfam11936
    Location:2444 → 2512
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:1995 → 2086
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:1942 → 1997
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:1989 → 2020
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Ciona intestinalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference KH Primary Assembly

Genomic

  1. NC_020174.2 Reference KH Primary Assembly

    Range
    4753230..4786088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Miscellaneous