eif3ba eukaryotic translation initiation factor 3, subunit Ba [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eif3baprovided by ZNC
Official Full Name: eukaryotic translation initiation factor 3, subunit Baprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2748
See related: Ensembl:ENSDARG00000059654 AllianceGenome:ZFIN:ZDB-GENE-030131-2748
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: eif3b; eif3s9; im:7152633; wu:fc17c01
Summary: Predicted to enable RNA binding activity and translation initiation factor binding activity. Predicted to contribute to translation initiation factor activity. Acts upstream of or within heart rudiment development and neural crest cell development. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Orthologous to human EIF3B (eukaryotic translation initiation factor 3 subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (41714966..41724932)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (41573108..41583074)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Eif3ba has a role in regulating cranial neural crest development by modulating p53 in zebrafish
Title: Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

AI641590 (e-PCR)
- UniSTS:206109

fc16e11.x1 (e-PCR)
- UniSTS:192800

RH124245 (e-PCR)
- UniSTS:161067

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart rudiment development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 3, subunit Ba

Names: eukaryotic translation initiation factor 3, subunit 9 eta; eukaryotic translation initiation factor 3, subunit B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290093.1 → NP_001277022.1 eukaryotic translation initiation factor 3, subunit Ba

Status: VALIDATED

Source sequence(s)

CT593959, CT625386, EB794365, EH433087, EH442533, EH468414

UniProtKB/TrEMBL

A0A8M1P0I6, X1WET9

Related

ENSDARP00000128740.1, ENSDART00000155440.2

Conserved Domains (4) summary

COG5354
Location:176 → 673

COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]

cd12278
Location:52 → 132

RRM_eIF3B; RNA recognition motif in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins

sd00039
Location:244 → 291

7WD40; WD40 repeat [structural motif]

cl02567
Location:206 → 447

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...