dhx33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dhx33provided by ZNC
Official Full Name: DEAH (Asp-Glu-Ala-His) box polypeptide 33provided by ZNC
Primary source: ZFIN:ZDB-GENE-131127-77
See related: Ensembl:ENSDARG00000051785 AllianceGenome:ZFIN:ZDB-GENE-131127-77
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-160e1.10
Summary: Predicted to enable RNA binding activity. Acts upstream of or within regulation of transcription by RNA polymerase I. Predicted to be active in nucleolus. Is expressed in central nervous system and digestive system. Orthologous to human DHX33 (DEAH-box helicase 33). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (1965320..1989556)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (1699995..1724231)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study demonstrates that DHX33 acts as a direct transcriptional regulator to promote cell cycle progression and plays an important role in driving cell proliferation during both embryo development and tumorigenesis.
Title: DHX33 Transcriptionally Controls Genes Involved in the Cell Cycle.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in intracellular anatomical structure	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP-dependent RNA helicase DHX33

Names: putative ATP-dependent RNA helicase DHX33-like

NP_001093527.3

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100057.2 → NP_001093527.3 ATP-dependent RNA helicase DHX33

Status: VALIDATED

Source sequence(s)

CT573103

UniProtKB/TrEMBL

A0A8M1NE29, X1WET4

Related

ENSDARP00000128735.1, ENSDART00000156224.2

Conserved Domains (5) summary

smart00487
Location:50 → 234

DEXDc; DEAD-like helicases superfamily

smart00847
Location:451 → 536

HA2; Helicase associated domain (HA2) Add an annotation

cd00046
Location:64 → 207

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00271
Location:264 → 381

Helicase_C; Helicase conserved C-terminal domain

pfam07717
Location:570 → 670

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold