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WIT1 WPP domain-interacting protein 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831010, updated on 15-Feb-2024

Summary

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Gene symbol
WIT1
Gene description
WPP domain-interacting protein 1
Primary source
Araport:AT5G11390
Locus tag
AT5G11390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F2I11.280; F2I11_280; WPP domain-interacting protein 1
Summary
Encodes one of the WPP domain-interacting proteins (WIT1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with the outer surface of the nuclear envelope in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of likely plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WIT1 and WIT2 have been identified as a second family of CC-TMD proteins, structurally similar, yet clearly distinct from the WIP family, that is required for RanGAP nuclear envelop association in root tip cells.
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Genomic context

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Location:
chromosome: 5
Exon count:
5
Sequence:
Chromosome: 5; NC_003076.8 (3633649..3636934)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene FBD / Leucine Rich Repeat domains containing protein Neighboring gene 1-deoxy-D-xylulose 5-phosphate synthase 3 Neighboring gene Protein kinase superfamily protein Neighboring gene Protein kinase superfamily protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Myosin XI-i links the nuclear membrane to the cytoskeleton to control nuclear movement and shape in Arabidopsis. Tamura K, et al. Curr Biol, 2013 Sep 23. PMID 23973298
  2. Two distinct interacting classes of nuclear envelope-associated coiled-coil proteins are required for the tissue-specific nuclear envelope targeting of Arabidopsis RanGAP. Zhao Q, et al. Plant Cell, 2008 Jun. PMID 18591351, Free PMC Article
  3. Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1. Zhou X, et al. Nucleus, 2015. PMID 25759303, Free PMC Article
  4. WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1. Brkljacic J, et al. Plant Physiol, 2009 Sep. PMID 19617588, Free PMC Article
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HSC70-1 and the WPP-domain proteins play a role in facilitating WIT1 nuclear envelope targeting. [WIT1]
    Title: WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_121177.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
WPP domain-interacting protein 1
NP_196700.2
  • WPP domain-interacting protein 1 (WIT1); BEST Arabidopsis thaliana protein match is: WPP domain-interacting protein 2 (TAIR:AT1G68910.1); Has 69833 Blast hits to 39390 proteins in 2372 species: Archae - 1132; Bacteria - 10633; Metazoa - 34082; Fungi - 6202; Plants - 3742; Viruses - 161; Other Eukaryotes - 13881 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    3633649..3636934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121177.4 → NP_196700.2  WPP domain-interacting protein 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196700.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8L7E5, Q9LFL8
    UniProtKB/TrEMBL
    A0A178UMG7, A0A5S9Y3K5, A0A654G052
    Conserved Domains (2) summary
    COG1196
    Location:245 → 585
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:81 → 397
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8L7E5.2

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